Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome
Abstract Background Urinary β2-microglobulin (Uβ2M) is elevated in tubulointerstitial nephritis and uveitis (TINU) syndrome and has emerged as an important diagnostic tool. This study aims to determine whether Uβ2M correlates with uveitis activity in TINU. Methods Retrospective observational case se...
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doaj-164522c7f38249839e2661019a288fb92020-11-25T01:08:10ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602018-12-01811710.1186/s12348-018-0166-3Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndromeLorraine M. Provencher0Aaron M. Fairbanks1Michael D. Abramoff2Nasreen A. Syed3Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and ClinicsDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and ClinicsDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and ClinicsDepartment of Ophthalmology and Visual Sciences, University of Iowa Hospitals and ClinicsAbstract Background Urinary β2-microglobulin (Uβ2M) is elevated in tubulointerstitial nephritis and uveitis (TINU) syndrome and has emerged as an important diagnostic tool. This study aims to determine whether Uβ2M correlates with uveitis activity in TINU. Methods Retrospective observational case series of nine patients with TINU and ≥ 30 days follow-up. Presenting symptoms, visual acuity, uveitis characteristics, follow-up, Uβ2M, serum creatinine (SCr), urinalysis, and renal biopsy results were collected. Results A correlation between Uβ2M and anterior chamber (AC) cell (r = 0.69, 95% CI 0.46–0.84), flare (r = 0.65, 95% CI 0.39–0.81), trended toward a stronger correlation than SCr and AC cell (r = 0.59, 95% CI 0.29–0.79), flare (r = 0.52, 95% CI 0.19–0.75). Uβ2M decreased over 1–2 years while SCr returned to normal within a few months. Conclusions Uβ2M correlate with uveitis activity and trend down over the course of TINU. Uβ2M may serve as a useful tool in determining where patients are in their systemic disease course.http://link.springer.com/article/10.1186/s12348-018-0166-3β2-microglobulinTubulointerstitialNephritisUveitisTINU |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lorraine M. Provencher Aaron M. Fairbanks Michael D. Abramoff Nasreen A. Syed |
spellingShingle |
Lorraine M. Provencher Aaron M. Fairbanks Michael D. Abramoff Nasreen A. Syed Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome Journal of Ophthalmic Inflammation and Infection β2-microglobulin Tubulointerstitial Nephritis Uveitis TINU |
author_facet |
Lorraine M. Provencher Aaron M. Fairbanks Michael D. Abramoff Nasreen A. Syed |
author_sort |
Lorraine M. Provencher |
title |
Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome |
title_short |
Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome |
title_full |
Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome |
title_fullStr |
Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome |
title_full_unstemmed |
Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome |
title_sort |
urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome |
publisher |
SpringerOpen |
series |
Journal of Ophthalmic Inflammation and Infection |
issn |
1869-5760 |
publishDate |
2018-12-01 |
description |
Abstract Background Urinary β2-microglobulin (Uβ2M) is elevated in tubulointerstitial nephritis and uveitis (TINU) syndrome and has emerged as an important diagnostic tool. This study aims to determine whether Uβ2M correlates with uveitis activity in TINU. Methods Retrospective observational case series of nine patients with TINU and ≥ 30 days follow-up. Presenting symptoms, visual acuity, uveitis characteristics, follow-up, Uβ2M, serum creatinine (SCr), urinalysis, and renal biopsy results were collected. Results A correlation between Uβ2M and anterior chamber (AC) cell (r = 0.69, 95% CI 0.46–0.84), flare (r = 0.65, 95% CI 0.39–0.81), trended toward a stronger correlation than SCr and AC cell (r = 0.59, 95% CI 0.29–0.79), flare (r = 0.52, 95% CI 0.19–0.75). Uβ2M decreased over 1–2 years while SCr returned to normal within a few months. Conclusions Uβ2M correlate with uveitis activity and trend down over the course of TINU. Uβ2M may serve as a useful tool in determining where patients are in their systemic disease course. |
topic |
β2-microglobulin Tubulointerstitial Nephritis Uveitis TINU |
url |
http://link.springer.com/article/10.1186/s12348-018-0166-3 |
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