Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine.
Tumourigenesis within the intestine is potently driven by deregulation of the Wnt pathway, a process epigenetically regulated by the chromatin remodelling factor Brg1. We aimed to investigate this interdependency in an in vivo setting and assess the viability of Brg1 as a potential therapeutic targe...
Main Authors: | Aliaksei Z Holik, Madeleine Young, Joanna Krzystyniak, Geraint T Williams, Daniel Metzger, Boris Y Shorning, Alan R Clarke |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-07-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4091792?pdf=render |
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