An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal Rest
We describe a case of a 61-year-old Korean man who was diagnosed with renal cell carcinoma that was discovered on abdominopelvic computed tomography obtained after the patient complained of back pain. A radical nephrectomy was performed, and the surgical specimen showed a relatively well-circumscrib...
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Korean Society of Pathologists & the Korean Society for Cytopathology
2018-11-01
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doaj-1664d815f1bd4d62b1314a7f0cb6ab472020-11-24T22:57:26ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452018-11-0152641641910.4132/jptm.2018.07.2016794An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal RestJi Hee Lee0Young Deuk Choi1Nam Hoon Cho2 Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDepartment of Urology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaWe describe a case of a 61-year-old Korean man who was diagnosed with renal cell carcinoma that was discovered on abdominopelvic computed tomography obtained after the patient complained of back pain. A radical nephrectomy was performed, and the surgical specimen showed a relatively well-circumscribed and yellowish lobulated hard mass. Microscopically, the tumor showed sheets and nests of hypercellular pleomorphic cells with thick fibrous septation, frequent mitoses, and areas of adrenal cortical-like tissue. Immunohistochemical staining revealed that the tumor cells were positive for inhibin-α, vimentin, synaptophysin, and melan A. It also revealed that the tumor cells were negative for pan-cytokeratin, epithelial membrane antigen, paired box 8, α-methylacyl-coenzyme A racemase, CD10, cytokeratin 7, carbonic anhydrase 9, c-Kit, renal cell carcinoma, transcription factor E3, human melanoma black 45, desmin, smooth muscle actin, S-100, chromogranin A, CD34, anaplastic lymphoma kinase, and integrase interactor 1. Based on these histopathological and immunohistochemical findings, we diagnosed the tumor as intrarenal adrenocortical carcinoma arising in an adrenal rest. Several cases of intrarenal adrenocortical carcinoma have been reported, although they are very rare. Due to its poor prognosis and common recurrence or metastasis, clinicians and pathologists must be aware of this entity.http://www.jpatholtm.org/upload/pdf/jptm-2018-07-20.pdfAdrenocortical carcinomaAdrenal rest tumorCarcinomaRenal cell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji Hee Lee Young Deuk Choi Nam Hoon Cho |
spellingShingle |
Ji Hee Lee Young Deuk Choi Nam Hoon Cho An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal Rest Journal of Pathology and Translational Medicine Adrenocortical carcinoma Adrenal rest tumor Carcinoma Renal cell |
author_facet |
Ji Hee Lee Young Deuk Choi Nam Hoon Cho |
author_sort |
Ji Hee Lee |
title |
An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal Rest |
title_short |
An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal Rest |
title_full |
An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal Rest |
title_fullStr |
An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal Rest |
title_full_unstemmed |
An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal Rest |
title_sort |
intrarenal adrenocortical carcinoma arising in an adrenal rest |
publisher |
Korean Society of Pathologists & the Korean Society for Cytopathology |
series |
Journal of Pathology and Translational Medicine |
issn |
2383-7837 2383-7845 |
publishDate |
2018-11-01 |
description |
We describe a case of a 61-year-old Korean man who was diagnosed with renal cell carcinoma that was discovered on abdominopelvic computed tomography obtained after the patient complained of back pain. A radical nephrectomy was performed, and the surgical specimen showed a relatively well-circumscribed and yellowish lobulated hard mass. Microscopically, the tumor showed sheets and nests of hypercellular pleomorphic cells with thick fibrous septation, frequent mitoses, and areas of adrenal cortical-like tissue. Immunohistochemical staining revealed that the tumor cells were positive for inhibin-α, vimentin, synaptophysin, and melan A. It also revealed that the tumor cells were negative for pan-cytokeratin, epithelial membrane antigen, paired box 8, α-methylacyl-coenzyme A racemase, CD10, cytokeratin 7, carbonic anhydrase 9, c-Kit, renal cell carcinoma, transcription factor E3, human melanoma black 45, desmin, smooth muscle actin, S-100, chromogranin A, CD34, anaplastic lymphoma kinase, and integrase interactor 1. Based on these histopathological and immunohistochemical findings, we diagnosed the tumor as intrarenal adrenocortical carcinoma arising in an adrenal rest. Several cases of intrarenal adrenocortical carcinoma have been reported, although they are very rare. Due to its poor prognosis and common recurrence or metastasis, clinicians and pathologists must be aware of this entity. |
topic |
Adrenocortical carcinoma Adrenal rest tumor Carcinoma Renal cell |
url |
http://www.jpatholtm.org/upload/pdf/jptm-2018-07-20.pdf |
work_keys_str_mv |
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