Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis
Enterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic re...
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doaj-16657f0b59404b2d96d70ff2166b4aa92020-11-25T01:18:34ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-10-011010.3389/fmicb.2019.02301460891Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalisFang TanPengfei SheLinying ZhouYiqing LiuLihua ChenZhen LuoYong WuEnterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound CD437 was found to have potent bactericidal effect on E. faecalis. In addition, CD437 exhibited synergistic effects when administered in combination with gentamicin and additive effects when combined with ceftriaxone sodium. CD437 also inhibited biofilm formation by E. faecalis and exerted bactericidal effect on mature biofilm. Moreover, CD437 exhibited antibacterial and anti-biofilm effects against Staphylococcus. No bactericidal action of CD437 was observed against the gram-negative bacillus, but Pseudomonas aeruginosa biofilm extracellular polymeric substances (EPS) matrix formation was reduced. Overall, these findings indicate that CD437 has the potential to be developed as a novel antibacterial drug.https://www.frontiersin.org/article/10.3389/fmicb.2019.02301/fullretinoidEnterococcus faecalisantibacterialresistancebiofilmsynergism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fang Tan Pengfei She Linying Zhou Yiqing Liu Lihua Chen Zhen Luo Yong Wu |
spellingShingle |
Fang Tan Pengfei She Linying Zhou Yiqing Liu Lihua Chen Zhen Luo Yong Wu Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis Frontiers in Microbiology retinoid Enterococcus faecalis antibacterial resistance biofilm synergism |
author_facet |
Fang Tan Pengfei She Linying Zhou Yiqing Liu Lihua Chen Zhen Luo Yong Wu |
author_sort |
Fang Tan |
title |
Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis |
title_short |
Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis |
title_full |
Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis |
title_fullStr |
Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis |
title_full_unstemmed |
Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against Enterococcus faecalis |
title_sort |
bactericidal and anti-biofilm activity of the retinoid compound cd437 against enterococcus faecalis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2019-10-01 |
description |
Enterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound CD437 was found to have potent bactericidal effect on E. faecalis. In addition, CD437 exhibited synergistic effects when administered in combination with gentamicin and additive effects when combined with ceftriaxone sodium. CD437 also inhibited biofilm formation by E. faecalis and exerted bactericidal effect on mature biofilm. Moreover, CD437 exhibited antibacterial and anti-biofilm effects against Staphylococcus. No bactericidal action of CD437 was observed against the gram-negative bacillus, but Pseudomonas aeruginosa biofilm extracellular polymeric substances (EPS) matrix formation was reduced. Overall, these findings indicate that CD437 has the potential to be developed as a novel antibacterial drug. |
topic |
retinoid Enterococcus faecalis antibacterial resistance biofilm synergism |
url |
https://www.frontiersin.org/article/10.3389/fmicb.2019.02301/full |
work_keys_str_mv |
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