Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis
Intestinal obstruction is a common disease requiring abdominal surgery with significant morbidity and mortality. Currently, an effective medical treatment for obstruction, other than surgical resection or decompression, does not exist. Si-Jun-Zi Decoction is a famous Chinese medicine used to repleni...
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doaj-167dd83fd3174a3283e3a6d70c9a61f22020-11-24T23:25:24ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882014-01-01201410.1155/2014/928579928579Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal HomeostasisXiangyang Yu0Zhigang Cui1Zhenli Zhou2Tao Shan3Donghua Li4Naiqiang Cui5Department of Gastrointestinal Surgery, Nankai Hospital, Nankai District, Tianjin 300100, ChinaGraduate School of Tianjin Medical University, Nankai District, Tianjin 300100, ChinaDepartment of Gastrointestinal Surgery, Nankai Hospital, Nankai District, Tianjin 300100, ChinaDepartment of Gastrointestinal Surgery, Nankai Hospital, Nankai District, Tianjin 300100, ChinaTianjin Institute of Acute Abdominal Disease of Integrated Traditional Chinese and Western Medicine, Nankai District, Tianjin 300100, ChinaDepartment of Hepatopancreatobiliary Surgery, Nankai Hospital, Nankai District, Tianjin 300100, ChinaIntestinal obstruction is a common disease requiring abdominal surgery with significant morbidity and mortality. Currently, an effective medical treatment for obstruction, other than surgical resection or decompression, does not exist. Si-Jun-Zi Decoction is a famous Chinese medicine used to replenish qi and invigorate the functions of the spleen. Modern pharmacological studies show that this prescription can improve gastrointestinal function and strengthen immune function. In this study, we investigated the effects of a famous Chinese herbal formula, Si-Jun-Zi Decoction, on the restoration of intestinal function after the relief of obstruction in a rabbit model. We found that Si-Jun-Zi Decoction could reduce intestinal mucosal injury while promoting the recovery of the small intestine. Further, Si-Jun-Zi Decoction could regulate the intestinal immune system. Our results suggest that Si-Jun-Zi Decoction promotes the restoration of intestinal function after obstruction by regulating intestinal homeostasis. Our observations indicate that Si-Jun-Zi Decoction is potentially a therapeutic drug for intestinal obstruction.http://dx.doi.org/10.1155/2014/928579 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiangyang Yu Zhigang Cui Zhenli Zhou Tao Shan Donghua Li Naiqiang Cui |
spellingShingle |
Xiangyang Yu Zhigang Cui Zhenli Zhou Tao Shan Donghua Li Naiqiang Cui Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis Evidence-Based Complementary and Alternative Medicine |
author_facet |
Xiangyang Yu Zhigang Cui Zhenli Zhou Tao Shan Donghua Li Naiqiang Cui |
author_sort |
Xiangyang Yu |
title |
Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis |
title_short |
Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis |
title_full |
Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis |
title_fullStr |
Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis |
title_full_unstemmed |
Si-Jun-Zi Decoction Treatment Promotes the Restoration of Intestinal Function after Obstruction by Regulating Intestinal Homeostasis |
title_sort |
si-jun-zi decoction treatment promotes the restoration of intestinal function after obstruction by regulating intestinal homeostasis |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2014-01-01 |
description |
Intestinal obstruction is a common disease requiring abdominal surgery with significant morbidity and mortality. Currently, an effective medical treatment for obstruction, other than surgical resection or decompression, does not exist. Si-Jun-Zi Decoction is a famous Chinese medicine used to replenish qi and invigorate the functions of the spleen. Modern pharmacological studies show that this prescription can improve gastrointestinal function and strengthen immune function. In this study, we investigated the effects of a famous Chinese herbal formula, Si-Jun-Zi Decoction, on the restoration of intestinal function after the relief of obstruction in a rabbit model. We found that Si-Jun-Zi Decoction could reduce intestinal mucosal injury while promoting the recovery of the small intestine. Further, Si-Jun-Zi Decoction could regulate the intestinal immune system. Our results suggest that Si-Jun-Zi Decoction promotes the restoration of intestinal function after obstruction by regulating intestinal homeostasis. Our observations indicate that Si-Jun-Zi Decoction is potentially a therapeutic drug for intestinal obstruction. |
url |
http://dx.doi.org/10.1155/2014/928579 |
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