The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates
Eukaryotic elongation factor 1 alpha (eEF1A) is subject to extensive post-translational methylation but not all responsible enzymes are known. Here, the authors identify METTL13 as an eEF1A methyltransferase with dual specificity, which is involved in the codon-specific modulation of mRNA translatio...
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05646-y |
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doaj-1682b8aad27f487895096c47624bca862021-05-11T09:25:26ZengNature Publishing GroupNature Communications2041-17232018-08-019111510.1038/s41467-018-05646-yThe dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation ratesMagnus E. Jakobsson0Jędrzej M. Małecki1Levon Halabelian2Benedikt S. Nilges3Rita Pinto4Srikanth Kudithipudi5Stephanie Munk6Erna Davydova7Fawzi R. Zuhairi8Cheryl H. Arrowsmith9Albert Jeltsch10Sebastian A. Leidel11Jesper V. Olsen12Pål Ø. Falnes13Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of OsloDepartment of Biosciences, Faculty of Mathematics and Natural Sciences, University of OsloStructural Genomics Consortium, and Princess Margaret Cancer Centre, University of TorontoMax Planck Research Group for RNA Biology, Max Planck Institute for Molecular BiomedicineDepartment of Biosciences, Faculty of Mathematics and Natural Sciences, University of OsloDepartment of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart UniversityProteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research (NNF-CPR), University of CopenhagenDepartment of Biosciences, Faculty of Mathematics and Natural Sciences, University of OsloDepartment of Biosciences, Faculty of Mathematics and Natural Sciences, University of OsloStructural Genomics Consortium, and Princess Margaret Cancer Centre, University of TorontoDepartment of Biochemistry, Institute of Biochemistry and Technical Biochemistry, Stuttgart UniversityMax Planck Research Group for RNA Biology, Max Planck Institute for Molecular BiomedicineProteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research (NNF-CPR), University of CopenhagenDepartment of Biosciences, Faculty of Mathematics and Natural Sciences, University of OsloEukaryotic elongation factor 1 alpha (eEF1A) is subject to extensive post-translational methylation but not all responsible enzymes are known. Here, the authors identify METTL13 as an eEF1A methyltransferase with dual specificity, which is involved in the codon-specific modulation of mRNA translation.https://doi.org/10.1038/s41467-018-05646-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Magnus E. Jakobsson Jędrzej M. Małecki Levon Halabelian Benedikt S. Nilges Rita Pinto Srikanth Kudithipudi Stephanie Munk Erna Davydova Fawzi R. Zuhairi Cheryl H. Arrowsmith Albert Jeltsch Sebastian A. Leidel Jesper V. Olsen Pål Ø. Falnes |
| spellingShingle |
Magnus E. Jakobsson Jędrzej M. Małecki Levon Halabelian Benedikt S. Nilges Rita Pinto Srikanth Kudithipudi Stephanie Munk Erna Davydova Fawzi R. Zuhairi Cheryl H. Arrowsmith Albert Jeltsch Sebastian A. Leidel Jesper V. Olsen Pål Ø. Falnes The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates Nature Communications |
| author_facet |
Magnus E. Jakobsson Jędrzej M. Małecki Levon Halabelian Benedikt S. Nilges Rita Pinto Srikanth Kudithipudi Stephanie Munk Erna Davydova Fawzi R. Zuhairi Cheryl H. Arrowsmith Albert Jeltsch Sebastian A. Leidel Jesper V. Olsen Pål Ø. Falnes |
| author_sort |
Magnus E. Jakobsson |
| title |
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates |
| title_short |
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates |
| title_full |
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates |
| title_fullStr |
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates |
| title_full_unstemmed |
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates |
| title_sort |
dual methyltransferase mettl13 targets n terminus and lys55 of eef1a and modulates codon-specific translation rates |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
Eukaryotic elongation factor 1 alpha (eEF1A) is subject to extensive post-translational methylation but not all responsible enzymes are known. Here, the authors identify METTL13 as an eEF1A methyltransferase with dual specificity, which is involved in the codon-specific modulation of mRNA translation. |
| url |
https://doi.org/10.1038/s41467-018-05646-y |
| work_keys_str_mv |
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