Association of single-nucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris
The glucocorticosteroid (GC) is crucial when managing patients with pemphigus vulgaris (PV). Polymorphisms in the gene encoding the nuclear receptor subfamily 3, group C, member 1 (NR3C1) protein (the GC receptor) may explain the variations in treatment efficacy. We evaluated the effects of 10 sing...
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doaj-168364228b484b31be96429df23bd63b2021-10-06T12:14:41ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062021-10-0110.4081/dr.2021.9190Association of single-nucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris Thai Van Thanh Le0Duy Quan Nguyen1Ngoc Dang Tran2Tu H.K. Trinh3Department of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh CityDepartment of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh CityDepartment of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh CityUniversity of Medicine and Pharmacy at Ho Chi Minh City, Vietnam The glucocorticosteroid (GC) is crucial when managing patients with pemphigus vulgaris (PV). Polymorphisms in the gene encoding the nuclear receptor subfamily 3, group C, member 1 (NR3C1) protein (the GC receptor) may explain the variations in treatment efficacy. We evaluated the effects of 10 single nucleotide polymorphisms (SNPs) in the NR3C1 gene and the correlations with the GC responsiveness in patients with PV. The accumulative GC doses were recorded, and patients were assessed for the Pemphigus Disease Activity Index (PDAI) scores until the GC doses would be tapered. Whole blood samples at the initial visit were genotyped using TaqMan SNP Genotyping. In the NR3C1 gene, SNPs were detected in 6 (rs17209237, rs11745958, rs7701443, rs41423247, rs33388, and rs6196); the genotypes rs17209237 AA, rs11745958 CC, and rs6196 AG may be associated with a need for a lower accumulative GC dose; rs17209237 AA and rs6196 AG with shorter times to commencement of tapering; and rs17209237 AA and rs11745958 CC with shorter times to attainment of 50 and 25% PDAI scores. Thus, NR3C1 gene variations may predict GC responsiveness in PV patients. https://www.pagepress.org/journals/index.php/dr/article/view/9190NR3C1 polymorphisms; Glucocorticosteroid; Pemphigus Vulgaris; Vietnamese patients |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thai Van Thanh Le Duy Quan Nguyen Ngoc Dang Tran Tu H.K. Trinh |
spellingShingle |
Thai Van Thanh Le Duy Quan Nguyen Ngoc Dang Tran Tu H.K. Trinh Association of single-nucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris Dermatology Reports NR3C1 polymorphisms; Glucocorticosteroid; Pemphigus Vulgaris; Vietnamese patients |
author_facet |
Thai Van Thanh Le Duy Quan Nguyen Ngoc Dang Tran Tu H.K. Trinh |
author_sort |
Thai Van Thanh Le |
title |
Association of single-nucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris |
title_short |
Association of single-nucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris |
title_full |
Association of single-nucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris |
title_fullStr |
Association of single-nucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris |
title_full_unstemmed |
Association of single-nucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris |
title_sort |
association of single-nucleotide nr3c1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris |
publisher |
PAGEPress Publications |
series |
Dermatology Reports |
issn |
2036-7392 2036-7406 |
publishDate |
2021-10-01 |
description |
The glucocorticosteroid (GC) is crucial when managing patients with pemphigus vulgaris (PV). Polymorphisms in the gene encoding the nuclear receptor subfamily 3, group C, member 1 (NR3C1) protein (the GC receptor) may explain the variations in treatment efficacy. We evaluated the effects of 10 single nucleotide polymorphisms (SNPs) in the NR3C1 gene and the correlations with the GC responsiveness in patients with PV. The accumulative GC doses were recorded, and patients were assessed for the Pemphigus Disease Activity Index (PDAI) scores until the GC doses would be tapered. Whole blood samples at the initial visit were genotyped using TaqMan SNP Genotyping. In the NR3C1 gene, SNPs were detected in 6 (rs17209237, rs11745958, rs7701443, rs41423247, rs33388, and rs6196); the genotypes rs17209237 AA, rs11745958 CC, and rs6196 AG may be associated with a need for a lower accumulative GC dose; rs17209237 AA and rs6196 AG with shorter times to commencement of tapering; and rs17209237 AA and rs11745958 CC with shorter times to attainment of 50 and 25% PDAI scores. Thus, NR3C1 gene variations may predict GC responsiveness in PV patients.
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topic |
NR3C1 polymorphisms; Glucocorticosteroid; Pemphigus Vulgaris; Vietnamese patients |
url |
https://www.pagepress.org/journals/index.php/dr/article/view/9190 |
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