NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia

NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia

Abstract Non-T cell activation linker (NTAL) is a lipid raft-membrane protein expressed by normal and leukemic cells and involved in cell signaling. In acute promyelocytic leukemia (APL), NTAL depletion from lipid rafts decreases cell viability through regulation of the Akt/PI3K pathway. The role of...

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Main Authors: Carolina Hassibe Thomé, Germano Aguiar Ferreira, Diego Antonio Pereira-Martins, Guilherme Augusto dos Santos, César Alexander Ortiz, Lucas Eduardo Botelho de Souza, Lays Martins Sobral, Cleide Lúcia Araújo Silva, Priscila Santos Scheucher, Cristiane Damas Gil, Andréia Machado Leopoldino, Douglas R. A. Silveira, Juan L. Coelho-Silva, Fabíola Traina, Luisa C. Koury, Raul A. M. Melo, Rosane Bittencourt, Katia Pagnano, Ricardo Pasquini, Elenaide C. Nunes, Evandro M. Fagundes, Ana Beatriz F. Gloria, Fábio Rodrigues Kerbauy, Maria de Lourdes Chauffaille, Armand Keating, Martin S. Tallman, Raul C. Ribeiro, Richard Dillon, Arnold Ganser, Bob Löwenberg, Peter Valk, Francesco Lo-Coco, Miguel A. Sanz, Nancy Berliner, Vitor Marcel Faça, Eduardo M. Rego
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-66223-2

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