The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction
<p><strong>Objective</strong> To analyze the effect of intensive lipid regulation treatment with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction. <strong>Methods </strong> Ninety-two patients wit...
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Tianjin Huanhu Hospital
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doaj-168c042385cf49449f3502b4cc119a882020-11-25T00:48:55ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312015-11-0115119049081295The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarctionShu XU0Qiu-yi WU1Gang GUO2Xin-sheng DING3Department of Neurology, Zhangjiagang First People's Hospital, Zhangjiagang 215600, Jiangsu, ChinaDepartment of Neurology, Zhangjiagang First People's Hospital, Zhangjiagang 215600, Jiangsu, ChinaDepartment of Neurology, Zhangjiagang First People's Hospital, Zhangjiagang 215600, Jiangsu, ChinaDepartment of Neurology, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210019, Jiangsu, China<p><strong>Objective</strong> To analyze the effect of intensive lipid regulation treatment with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction. <strong>Methods </strong> Ninety-two patients with atherosclerotic cerebral infarction were randomly divided into two groups: observation group (treated by atorvastatin calcium with the dosage of 20 mg/d, N = 46) and control group (treated by diet without lipid-rich food, N=46). Besides, other drugs given to the patients in two groups were the same. The blood lipid levels and the changes of carotid artery plaques in two groups were analyzed and compared before treatment and 3 months after treatment. <strong> Results</strong> After treatment, the concentrations of total cholesterol [TC, (4.23 ± 0.92) mmol/L vs (5.24 ± 0.68) mmol/L], triglyceride [TG, (2.46 ± 0.28) mmol/L vs (3.33 ± 0.47) mmol/L], low-density lipoprotein cholesterol [LDL-C, (2.52 ± 0.38) mmol/L vs (4.78 ± 0.86) mmol/L] in the patients of observation group were all decreased and significantly lower than those in the control group (P = 0.000, for all), and the concentration of high-density lipoprotein cholesterol [HDL-C, (1.13 ± 0.41) mmol/L vs (0.85 ± 0.32) mmol/L] in the patients of observation group was increased and significantly than that in the control group (<em>P</em> = 0.003). The carotid artery plaque size [(20.25 ± 0.32) mm<sup>2</sup> vs (24.42 ± 10.33) mm<sup>2</sup>] and thickness [(0.59 ± 0.13) mm vs (1.93 ± 0.23) mm] of carotid artery plaques and intima?media thickness [IMT, (1.32 ± 0.67) mm vs (1.63 ± 0.56) mm] of common carotid artery (CCA) in the patients of observation group were all significantly lower than those in patients in the control group (<em>P</em> = 0.000, 0.000, 0.010, respectively). Comparing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK) and creatinine (Cr) levels after treatment with before treatment, there was no significant difference between 2 groups (<em>P</em> > 0.05, for all). <strong>Conclusions</strong> Atorvastatin can effectively improve the abnormal blood lipids and soften or even lessen the carotid artery plaques in patients with atherosclerotic cerebral infarction, therefore it is helpful to the second prevention of cerebral infarction with no obvious adverse reactions.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.11.014</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1309Brain infarctionAtherosclerosisAntilipemic agents |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shu XU Qiu-yi WU Gang GUO Xin-sheng DING |
spellingShingle |
Shu XU Qiu-yi WU Gang GUO Xin-sheng DING The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction Chinese Journal of Contemporary Neurology and Neurosurgery Brain infarction Atherosclerosis Antilipemic agents |
author_facet |
Shu XU Qiu-yi WU Gang GUO Xin-sheng DING |
author_sort |
Shu XU |
title |
The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction |
title_short |
The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction |
title_full |
The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction |
title_fullStr |
The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction |
title_full_unstemmed |
The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction |
title_sort |
effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2015-11-01 |
description |
<p><strong>Objective</strong> To analyze the effect of intensive lipid regulation treatment with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction. <strong>Methods </strong> Ninety-two patients with atherosclerotic cerebral infarction were randomly divided into two groups: observation group (treated by atorvastatin calcium with the dosage of 20 mg/d, N = 46) and control group (treated by diet without lipid-rich food, N=46). Besides, other drugs given to the patients in two groups were the same. The blood lipid levels and the changes of carotid artery plaques in two groups were analyzed and compared before treatment and 3 months after treatment. <strong> Results</strong> After treatment, the concentrations of total cholesterol [TC, (4.23 ± 0.92) mmol/L vs (5.24 ± 0.68) mmol/L], triglyceride [TG, (2.46 ± 0.28) mmol/L vs (3.33 ± 0.47) mmol/L], low-density lipoprotein cholesterol [LDL-C, (2.52 ± 0.38) mmol/L vs (4.78 ± 0.86) mmol/L] in the patients of observation group were all decreased and significantly lower than those in the control group (P = 0.000, for all), and the concentration of high-density lipoprotein cholesterol [HDL-C, (1.13 ± 0.41) mmol/L vs (0.85 ± 0.32) mmol/L] in the patients of observation group was increased and significantly than that in the control group (<em>P</em> = 0.003). The carotid artery plaque size [(20.25 ± 0.32) mm<sup>2</sup> vs (24.42 ± 10.33) mm<sup>2</sup>] and thickness [(0.59 ± 0.13) mm vs (1.93 ± 0.23) mm] of carotid artery plaques and intima?media thickness [IMT, (1.32 ± 0.67) mm vs (1.63 ± 0.56) mm] of common carotid artery (CCA) in the patients of observation group were all significantly lower than those in patients in the control group (<em>P</em> = 0.000, 0.000, 0.010, respectively). Comparing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK) and creatinine (Cr) levels after treatment with before treatment, there was no significant difference between 2 groups (<em>P</em> > 0.05, for all). <strong>Conclusions</strong> Atorvastatin can effectively improve the abnormal blood lipids and soften or even lessen the carotid artery plaques in patients with atherosclerotic cerebral infarction, therefore it is helpful to the second prevention of cerebral infarction with no obvious adverse reactions.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.11.014</p> |
topic |
Brain infarction Atherosclerosis Antilipemic agents |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/1309 |
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