<b><i>In vitro</i> synergistic activity of lidocaine and miconazole against <i>Candida albicans

• Main Authors: Maria da Conceição dos Santos Oliveira Cunha, Tarcísio Paulo de Almeida Filho, Francisco Afrânio Cunha, Ana Gesselena da Silva Farias, Ieda Pereira de Souza, Everardo Albuquerque Menezes
• Format: Article
• Language: English
• Published: Universidade Estadual de Maringá 2017-08-01
• Series: Acta Scientiarum. Health Sciences
• Subjects: vulvovaginal candidiasis; antifungal agents; local anesthetic.
• Online Access: http://periodicos.uem.br/ojs/index.php/ActaSciHealthSci/article/view/32413

Candida albicans is the main yeast isolated from vulvovaginal candidiasis(VVC) and a major antifungal used to treat VVC is miconazole (MZ), it shows local toxic effects, such as irritation and burns. The lidocaine (LD) is a local anesthetic. The aim of this study was to evaluate the synergistic activity of LD/MZ against 19 strains of C. albicans isolated from vaginal secretion. 78.9% of the strains were susceptible to the combination LD/MZ, demonstrating synergism of drugs. These drugs can be used to produce vaginal creams to treat VVC, especially drug resistant.