The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury

The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury

Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on rena...

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Bibliographic Details
Main Authors: Worapat Prachasilchai, Hiroko Sonoda, Naoko Yokota-Ikeda, Katsuaki Ito, Takashi Kudo, Kazunori Imaizumi, Masahiro Ikeda
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319312873
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Summary:Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Coadministration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury. Keywords:: renal ischemia-reperfusion injury, endoplasmic reticulum (ER) stress, unfolded protein response
ISSN:1347-8613

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