The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury

The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury

Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on rena...

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Main Authors: Worapat Prachasilchai, Hiroko Sonoda, Naoko Yokota-Ikeda, Katsuaki Ito, Takashi Kudo, Kazunori Imaizumi, Masahiro Ikeda
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319312873
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spelling doaj-16a4a00c7f2f48edb4e0d08550cf707d2020-11-25T02:06:26ZengElsevierJournal of Pharmacological Sciences1347-86132009-01-011092311314The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney InjuryWorapat Prachasilchai0Hiroko Sonoda1Naoko Yokota-Ikeda2Katsuaki Ito3Takashi Kudo4Kazunori Imaizumi5Masahiro Ikeda6Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanNephrology Division, Miyazaki Prefectural Miyazaki Hospital, Miyazaki 880-8510, JapanDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanPsychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, JapanDivision of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, JapanDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan; Corresponding author. a0d302u@cc.miyazaki-u.ac.jpActivation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Coadministration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury. Keywords:: renal ischemia-reperfusion injury, endoplasmic reticulum (ER) stress, unfolded protein responsehttp://www.sciencedirect.com/science/article/pii/S1347861319312873
collection DOAJ
language English
format Article
sources DOAJ
author Worapat Prachasilchai
Hiroko Sonoda
Naoko Yokota-Ikeda
Katsuaki Ito
Takashi Kudo
Kazunori Imaizumi
Masahiro Ikeda
spellingShingle Worapat Prachasilchai
Hiroko Sonoda
Naoko Yokota-Ikeda
Katsuaki Ito
Takashi Kudo
Kazunori Imaizumi
Masahiro Ikeda
The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury
Journal of Pharmacological Sciences
author_facet Worapat Prachasilchai
Hiroko Sonoda
Naoko Yokota-Ikeda
Katsuaki Ito
Takashi Kudo
Kazunori Imaizumi
Masahiro Ikeda
author_sort Worapat Prachasilchai
title The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury
title_short The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury
title_full The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury
title_fullStr The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury
title_full_unstemmed The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury
title_sort protective effect of a newly developed molecular chaperone– inducer against mouse ischemic acute kidney injury
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2009-01-01
description Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Coadministration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury. Keywords:: renal ischemia-reperfusion injury, endoplasmic reticulum (ER) stress, unfolded protein response
url http://www.sciencedirect.com/science/article/pii/S1347861319312873
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