Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.
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2019-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-08154-1 |
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doaj-16b94020768b4b0886330aa70dd0da0d2021-05-11T12:13:26ZengNature Publishing GroupNature Communications2041-17232019-01-0110111610.1038/s41467-018-08154-1Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformationXiuquan Ma0Luxi Zhang1Jiangning Song2Elizabeth Nguyen3Rachel S. Lee4Samuel J. Rodgers5Fuyi Li6Cheng Huang7Ralf B. Schittenhelm8Howard Chan9Chanly Chheang10Jianmin Wu11Kristin K. Brown12Christina A. Mitchell13Kaylene J. Simpson14Roger J. Daly15Cancer Program, Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityDepartment of Biochemistry and Molecular Biology, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityDepartment of Biochemistry and Molecular Biology, Monash UniversityMonash Biomedical Proteomics Facility and Monash Biomedicine Discovery Institute, Monash UniversityMonash Biomedical Proteomics Facility and Monash Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Centre for Cancer Bioinformatics, Peking University Cancer Hospital & InstituteCancer Therapeutics Program and Cancer Metabolism Program, Peter MacCallum Cancer CentreCancer Program, Biomedicine Discovery Institute, Monash UniversitySir Peter MacCallum Department of Oncology, The University of MelbourneCancer Program, Biomedicine Discovery Institute, Monash UniversityThe systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.https://doi.org/10.1038/s41467-018-08154-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly |
spellingShingle |
Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation Nature Communications |
author_facet |
Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly |
author_sort |
Xiuquan Ma |
title |
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation |
title_short |
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation |
title_full |
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation |
title_fullStr |
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation |
title_full_unstemmed |
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation |
title_sort |
characterization of the src-regulated kinome identifies sgk1 as a key mediator of src-induced transformation |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-01-01 |
description |
The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation. |
url |
https://doi.org/10.1038/s41467-018-08154-1 |
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