Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.

Bibliographic Details
Main Authors:	Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S. Lee, Samuel J. Rodgers, Fuyi Li, Cheng Huang, Ralf B. Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K. Brown, Christina A. Mitchell, Kaylene J. Simpson, Roger J. Daly
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-08154-1

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spelling	doaj-16b94020768b4b0886330aa70dd0da0d2021-05-11T12:13:26ZengNature Publishing GroupNature Communications2041-17232019-01-0110111610.1038/s41467-018-08154-1Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformationXiuquan Ma0Luxi Zhang1Jiangning Song2Elizabeth Nguyen3Rachel S. Lee4Samuel J. Rodgers5Fuyi Li6Cheng Huang7Ralf B. Schittenhelm8Howard Chan9Chanly Chheang10Jianmin Wu11Kristin K. Brown12Christina A. Mitchell13Kaylene J. Simpson14Roger J. Daly15Cancer Program, Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityDepartment of Biochemistry and Molecular Biology, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityDepartment of Biochemistry and Molecular Biology, Monash UniversityMonash Biomedical Proteomics Facility and Monash Biomedicine Discovery Institute, Monash UniversityMonash Biomedical Proteomics Facility and Monash Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityCancer Program, Biomedicine Discovery Institute, Monash UniversityKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Centre for Cancer Bioinformatics, Peking University Cancer Hospital & InstituteCancer Therapeutics Program and Cancer Metabolism Program, Peter MacCallum Cancer CentreCancer Program, Biomedicine Discovery Institute, Monash UniversitySir Peter MacCallum Department of Oncology, The University of MelbourneCancer Program, Biomedicine Discovery Institute, Monash UniversityThe systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.https://doi.org/10.1038/s41467-018-08154-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly
spellingShingle	Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation Nature Communications
author_facet	Xiuquan Ma Luxi Zhang Jiangning Song Elizabeth Nguyen Rachel S. Lee Samuel J. Rodgers Fuyi Li Cheng Huang Ralf B. Schittenhelm Howard Chan Chanly Chheang Jianmin Wu Kristin K. Brown Christina A. Mitchell Kaylene J. Simpson Roger J. Daly
author_sort	Xiuquan Ma
title	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_short	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_full	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_fullStr	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_full_unstemmed	Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
title_sort	characterization of the src-regulated kinome identifies sgk1 as a key mediator of src-induced transformation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.
url	https://doi.org/10.1038/s41467-018-08154-1
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Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

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