Insidious fatal perforation of palate: A diagnostic challenge

• Main Authors: R Guru Prasad, Akshay Sujith, Neeta Sharma, Brijesh Kumar
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2020-01-01
• Series: Journal of Indian Academy of Oral Medicine and Radiology
• Subjects: antineutrophilic cytoplasmic antibodies; granulomatosis polyangiitis; perforation of palate; wegener's granulomatosis
• Online Access: http://www.jiaomr.in/article.asp?issn=0972-1363;year=2020;volume=32;issue=3;spage=293;epage=296;aulast=Prasad

Granulomatosis with polyangiitis (GPA) is considered as a systemic triad of necrotizing granulomatous vasculitis of the upper and lower respiratory tracts (pulmonary vasculitis) and a rapidly progressive glomerulonephritis. Few cases of a superficial form with only oral involvement are reported. The purpose of this article is to describe the steps in reaching a conclusive diagnosis in lesions involving the palate. Since in most cases the histopathological report will turn inconclusive, proper clinical evaluation and definitive diagnostic test like the estimation of cytoplasmic-antineutrophilic cytoplasmic antibody will be mandatory for obtaining a conclusive result.