p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification.

p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification.

E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs). E-cadherin-depleted mESC fail to downregulate their pluripotency program and are unable to initiate lineage commitment. To further explore the roles of cell adhesion molecules du...

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Bibliographic Details
Main Authors: Tim Pieters, Steven Goossens, Lieven Haenebalcke, Vanessa Andries, Agata Stryjewska, Riet De Rycke, Kelly Lemeire, Tino Hochepied, Danny Huylebroeck, Geert Berx, Marc P Stemmler, Dagmar Wirth, Jody J Haigh, Jolanda van Hengel, Frans van Roy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4996431?pdf=render

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