NSAID induced perforated peptic ulcer in a pediatric sickle cell patient

• Main Authors: Crystal Johnson-Mann, Kathryn Rawlings, Ricardo A. Arbizu, Andre Hebra
• Format: Article
• Language: English
• Published: Elsevier 2016-11-01
• Series: Journal of Pediatric Surgery Case Reports
• Subjects: Perforated ulcer; NSAID; Sickle cell disease
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213576616301440

Peptic ulcer disease is a relatively rare entity in the pediatric population. Given the trend toward multimodal pain control for pain crises in Sickle Cell Disease patients, they are at an increased risk of developing complications secondary to peptic ulcer disease. We discuss a case of a Sickle Cell Disease patient on multimodal therapy that presented with a perforated peptic ulcer requiring emergent surgery. While multimodal therapy helps ease the dependency on narcotic pain medication, it does present other potential problems like potential bleeding or perforation. For those that can be categorized in this select group of patients, routine surveillance with esophagogastroduodenoscopy should be considered for those at highest risk to prevent devastating complications.