Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1,3-Diketones

Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1,3-Diketones

A series of fourteen new asymmetrical 1,3-diketone derivatives have been synthesized and evaluated in the ABTS, FRAP and DPPH assays as a new chemotype with antioxidant and drug-like properties. All the compounds displayed low cytotoxicity in comparison to curcumin against the human neuroblastoma SH...

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Bibliographic Details
Main Authors: Carla I. Nieto, María Pilar Cornago, María Pilar Cabildo, Dionisia Sanz, Rosa M. Claramunt, María Carmen Torralba, María Rosario Torres, Diana Martínez Casanova, Yaiza Rebeca Sánchez-Alegre, Esther Escudero, José Luis Lavandera
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
neurodegeneration
oxidative stress
neuroprotectant
antioxidant
β-diketones
drug-like properties
Online Access:http://www.mdpi.com/1420-3049/23/8/1837

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