Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer
Xuefeng Yu,1,* Fulan Hu,2,* Chunfeng Li,1 Qiang Yao,1 Hongfeng Zhang,1 Yingwei Xue1 1Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, China; 2Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Ch...
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doaj-16ddac6f46644ec6934d41ddc1bf60fc2020-11-24T21:14:25ZengDove Medical PressOncoTargets and Therapy1178-69302018-02-01Volume 111037104436968Clinicopathologic characteristics and prognosis of proximal and distal gastric cancerYu XHu FLi CYao QZhang HXue YXuefeng Yu,1,* Fulan Hu,2,* Chunfeng Li,1 Qiang Yao,1 Hongfeng Zhang,1 Yingwei Xue1 1Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, China; 2Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, China *These authors contributed equally to this work Background and objectives: The dismal prognosis of gastric cancer patients is a global problem. We aim to evaluate the clinicopathologic features and prognostic factors of proximal and distal gastric cancer.Materials and methods: Gastric cancer cases diagnosed and treated at the same surgical unit between 2007 and 2010 were reviewed. Follow-up data from all patients were collected for at least 5 years until 2015. A total of 964 patients were studied (distal gastric cancer [DG], n=777 and proximal gastric cancer [PG], n=187).Results: DG patients had a relatively higher percentage of females, more thorough therapy (R0 [D0/D1/D2]), fewer combined organ resections, younger age, smaller tumors (<5 cm), shorter surgery durations, less blood loss during surgery, and a relatively lower percentage of nodal metastases and a TNM stage of 4 (p<0.05). A significantly higher 5-year survival rate was observed in DG patients compared to PG patients (DG: 51%, PG: 28%; p<0.001). A multivariate analysis demonstrated that tumor size, blood loss during surgery, surgery approach of lymph node dissection, treatment with palliative surgery, histopathologic type, TNM stage, and tumor location were independent predictors of poor outcome.Conclusion: The different characteristics and prognosis of DG and PG cases have implications for the development of guiding strategies for a surgical program and assessment of prognosis of gastric cancer patients based on tumor location. Keywords: gastric cancer, tumor location, clinicopathologic features, prognosis, distal gastric cancer, proximal gastric cancer https://www.dovepress.com/clinicopathologic-characteristics-and-prognosis-of-proximal-and-distal-peer-reviewed-article-OTTgastric cancertumor locationclinicopathological featuresprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu X Hu F Li C Yao Q Zhang H Xue Y |
spellingShingle |
Yu X Hu F Li C Yao Q Zhang H Xue Y Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer OncoTargets and Therapy gastric cancer tumor location clinicopathological features prognosis |
author_facet |
Yu X Hu F Li C Yao Q Zhang H Xue Y |
author_sort |
Yu X |
title |
Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer |
title_short |
Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer |
title_full |
Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer |
title_fullStr |
Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer |
title_full_unstemmed |
Clinicopathologic characteristics and prognosis of proximal and distal gastric cancer |
title_sort |
clinicopathologic characteristics and prognosis of proximal and distal gastric cancer |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2018-02-01 |
description |
Xuefeng Yu,1,* Fulan Hu,2,* Chunfeng Li,1 Qiang Yao,1 Hongfeng Zhang,1 Yingwei Xue1 1Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, China; 2Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, China *These authors contributed equally to this work Background and objectives: The dismal prognosis of gastric cancer patients is a global problem. We aim to evaluate the clinicopathologic features and prognostic factors of proximal and distal gastric cancer.Materials and methods: Gastric cancer cases diagnosed and treated at the same surgical unit between 2007 and 2010 were reviewed. Follow-up data from all patients were collected for at least 5 years until 2015. A total of 964 patients were studied (distal gastric cancer [DG], n=777 and proximal gastric cancer [PG], n=187).Results: DG patients had a relatively higher percentage of females, more thorough therapy (R0 [D0/D1/D2]), fewer combined organ resections, younger age, smaller tumors (<5 cm), shorter surgery durations, less blood loss during surgery, and a relatively lower percentage of nodal metastases and a TNM stage of 4 (p<0.05). A significantly higher 5-year survival rate was observed in DG patients compared to PG patients (DG: 51%, PG: 28%; p<0.001). A multivariate analysis demonstrated that tumor size, blood loss during surgery, surgery approach of lymph node dissection, treatment with palliative surgery, histopathologic type, TNM stage, and tumor location were independent predictors of poor outcome.Conclusion: The different characteristics and prognosis of DG and PG cases have implications for the development of guiding strategies for a surgical program and assessment of prognosis of gastric cancer patients based on tumor location. Keywords: gastric cancer, tumor location, clinicopathologic features, prognosis, distal gastric cancer, proximal gastric cancer |
topic |
gastric cancer tumor location clinicopathological features prognosis |
url |
https://www.dovepress.com/clinicopathologic-characteristics-and-prognosis-of-proximal-and-distal-peer-reviewed-article-OTT |
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