Effects of Ursolic Acid Derivatives on Caco-2 Cells and Their Alleviating Role in Streptozocin-Induced Type 2 Diabetic Rats

Effects of Ursolic Acid Derivatives on Caco-2 Cells and Their Alleviating Role in Streptozocin-Induced Type 2 Diabetic Rats

In this study, the effect and mechanism of a series of ursolic acid (UA) derivatives on glucose uptake were investigated in a Caco-2 cells model. Their effect on hyperglycemia, hyperlipidemia and oxidative stress were also demonstrated in streptozocin (STZ)-induced diabetic rats. 2-[N-(7-nitrobenz-2...

Full description

Bibliographic Details
Main Authors:	Panpan Wu, Ping He, Suqing Zhao, Tianming Huang, Yujing Lu, Kun Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2014-08-01
Series:	Molecules
Subjects:	diabetes mellitus ursolic acid derivatives Caco-2 cell 2-NBDG streptozotocin (STZ)-induced diabetic rat
Online Access:	http://www.mdpi.com/1420-3049/19/8/12559

Similar Items

Streptozotocin - an antibiotic used to induce diabetes on experimental animals
by: Dagna Siedlecka, et al.
Published: (2020-09-01)

Beneficial Hypoglycemic, Hypolipidemic Effects of Aerial Branches and Roots Extract of Eryngium caeruleum M. Bieb on Streptozotocin-Induced Diabetes Model in Rats
by: Aryaneh Sardarbandeh, et al.
Published: (2021-06-01)

Evaluating STZ-Induced Impaired Wound Healing in Rats
by: Ansell, David M., et al.
Published: (2020)

Effect of natural honey from Ilam and metformin for improving glycemic control in streptozotocin-induced diabetic rats
by: Ozra Nasrolahi, et al.
Published: (2012-09-01)

Rat Diabetic Blood Glucose Level Profile with Stratified Dose Streptozotocin (SD-STZ) and Multi Low Dose Streptozotocin (MLD-STZ) Induction Methods
by: Nuzulul Hikmah, et al.
Published: (2015-01-01)

Inflammatory Macrophages Promotes Development of Diabetic Encephalopathy
by: Beiyun Wang, et al.
Published: (2015-06-01)

A cell-based fluorescent glucose transporter assay for SGLT2 inhibitor discovery
by: Yi Huan, et al.
Published: (2013-04-01)

In vitro capacity and in vivo antioxidant potency of sedimental extract of Tinospora cordifolia in streptozotocin induced type 2 diabetes
by: Ramachandran Kannadhasan, et al.
Published: (2012-12-01)

Amelioration of Diabetes mellitus by modulation of GLP-1 via targeting alpha-glucosidase using Acacia tortilis polysaccharide in Streptozotocin-Nicotinamide induced diabetes in rats
by: Pradeep Kumar Bhateja, et al.
Published: (2020-10-01)

Anti-cataract effects of coconut water in vivo and in vitro
by: Xiaohua Zhang, et al.
Published: (2021-11-01)

Effect Of Keren Fruit Extract (Muntingia calabura) On Blood Glucose Levels Of Rats (Rattus novergicus) Which Induced By Streptozotocin (STZ)
by: Vembriarto Jati Pramono, et al.
Published: (2015-06-01)

The influence of elevated glucose levels and the diabetic state on neuromuscular function in the gut
by: Talubmook, Chusri
Published: (2002)

Diosmin, a Citrus Nutrient, Activates Imidazoline Receptors to Alleviate Blood Glucose and Lipids in Type 1-Like Diabetic Rats
by: Chia-Chen Hsu, et al.
Published: (2017-06-01)

A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells
by: Yan-Ting Lu, et al.
Published: (2018-11-01)

Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats
by: Y.S. Jaiswal, et al.
Published: (2017-10-01)

The Effects of stingless bee (Tetragonula biroi) honey on streptozotocin-induced diabetes mellitus in rats
by: Muhamad Sahlan, et al.
Published: (2020-08-01)

Renoprotective Effect of the Recombinant Anti-IL-6R Fusion Proteins by Inhibiting JAK2/STAT3 Signaling Pathway in Diabetic Nephropathy
by: Nanwen Zhang, et al.
Published: (2021-05-01)

Therapeutic Effect of Cilostazol Ophthalmic Nanodispersions on Retinal Dysfunction in Streptozotocin-Induced Diabetic Rats
by: Noriaki Nagai, et al.
Published: (2017-09-01)

Level of mRNA Insulin Gene and Blood Glucose STZ-Induced Diabetic Rat are Improved by Glucomannan of Amorphophallus muelleri Blume from East Java Forest Indonesia
by: Fatchiyah Fatchiyah, et al.
Published: (2019-05-01)

Antioxidant Effects of Biochanin A in Streptozotocin Induced Diabetic Rats
by: Hamideh Sadri, et al.
Published: (2017-08-01)

Effect of three months aerobic training on TCF7L2 expression in pancreatic tissue in type 2 diabetes rats induced by streptozotocin- nicotinamide
by: Mojtaba Eizadi, et al.
Published: (2017-04-01)

LC-MS-Based Untargeted Metabolomics Reveals Early Biomarkers in STZ-Induced Diabetic Rats With Cognitive Impairment
by: Ruijuan Chen, et al.
Published: (2021-06-01)

Exploration of the preventive effect of ursolic acid on retinopathy in diabetic mice and its mechanism
by: Ai-Zhong Yu
Published: (2016-07-01)

Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus
by: Adriana Elena Bulboacă, et al.
Published: (2019-02-01)

Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway
by: Ma TK, et al.
Published: (2019-12-01)

Novel High-Fat Diet Formulation and Streptozotocin Treatment for Induction of Prediabetes and Type 2 Diabetes in Rats
by: Nasimeh Vatandoust, et al.
Published: (2018-01-01)

Hypoglycemic effect of Bromelia plumieri (E. Morren) L.B. Sm., leaves in STZ-NA-induced diabetic rats.
by: Adolfo eAndrade-Cetto, et al.
Published: (2013-04-01)

Antioxidant-Rich Extract from Plantaginis Semen Ameliorates Diabetic Retinal Injury in a Streptozotocin-Induced Diabetic Rat Model
by: Thing-Fong Tzeng, et al.
Published: (2016-09-01)

Antidiabetic activity of Schkuhria pinnata – Biological screening, PK analysis and mode of action
by: Sewnarain, Prenitha
Published: (2021)

Antidiabetic and hepatoprotective activity of the roots of Calanthe fimbriata Franch
by: Yajie Peng, et al.
Published: (2019-03-01)

Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis
by: Ye Feng, et al.
Published: (2020-07-01)

Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito
by: Shigekuni Hosogi, et al.
Published: (2018-11-01)

Garlic and Resveratrol attenuate diabetic complications, loss of β-cells, pancreatic and hepatic oxidative stress in streptozotocin-induced diabetic rats
by: Gagandeep Kaur, et al.
Published: (2016-10-01)

Multidirectional Effects of Tormentil Extract on Hemostasis in Experimental Diabetes
by: Natalia Marcinczyk, et al.
Published: (2021-05-01)

Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats
by: Shih-Hsiang Lo, et al.
Published: (2017-06-01)

In Vitro Antioxidant Effects of Aloe barbadensis Miller Extracts and the Potential Role of These Extracts as Antidiabetic and Antilipidemic Agents on Streptozotocin-Induced Type 2 Diabetic Model Rats
by: Md. Ibrahim Khalil, et al.
Published: (2012-11-01)

Standardization of type 1 and type 2 diabetic nephropathy models in rats: Assessment and characterization of metabolic features and renal injury
by: Aakruti A Kaikini, et al.
Published: (2020-01-01)

High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal
by: DIEGO A. DE MAGALHÃES, et al.
Published: (2019-03-01)

The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity
by: Magdalena Gajęcka, et al.
Published: (2017-06-01)

Isolation and Characterisation of Anti-diabetic Pharmacological Activities of Phytoestrogens
by: D Roostaei, et al.
Published: (2016-08-01)