An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery Disease
Emerging evidence from randomized controlled clinical trials (RCTs) suggests that colchicine has cardiovascular benefits for patients with coronary disease, including benefits for stroke prevention. We performed an updated systematic review and meta-analysis of all RCTs reporting on stroke outcomes...
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doaj-16ea4c549adb4a7e86347f02fa2031272021-07-23T13:48:05ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-01103110311010.3390/jcm10143110An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery DiseaseAristeidis H. Katsanos0Lina Palaiodimou1Christopher Price2Marios Themistocleous3Robin Lemmens4Ioannis Michopoulos5Marios K. Georgakis6Christian Weimar7Peter Kelly8Georgios Tsivgoulis9Division of Neurology, Population Health Research Institute & McMaster University, Hamilton, ON L8S 4L8, CanadaSecond Department of Neurology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, 45701 Athens, GreecePopulation Health Sciences Institute, Newcastle University, Newcastle NE1 7RU, UKDepartment of Neurosurgery, Pediatric Hospital of Athens, 45701 Athens, GreeceDepartment of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven—University of Leuven, B-3000 Leuven, BelgiumSecond Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, “Attikon” General Hospital, 45701 Athens, GreeceInstitute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-University, 81377 Munich, GermanyInstitute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, 47057 Duisburg, GermanyHealth Research Board Stroke Clinical Trials Network Ireland and Mater University Hospital, University College Dublin, D04 V1W8 Dublin, IrelandSecond Department of Neurology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, 45701 Athens, GreeceEmerging evidence from randomized controlled clinical trials (RCTs) suggests that colchicine has cardiovascular benefits for patients with coronary disease, including benefits for stroke prevention. We performed an updated systematic review and meta-analysis of all RCTs reporting on stroke outcomes during the follow-up of patients with a history of cardiovascular disease randomized to colchicine treatment or control (placebo or usual care). We identified 6 RCTs including a total of 11,870 patients (mean age 63 years, 83% males) with a mean follow-up of 2 years. Colchicine treatment was associated with a lower risk of stroke during follow-up, compared to that of placebo or usual care (risk ratio = 0.49, 95% confidence interval: 0.31–0.80; <i>p</i> = 0.004), without heterogeneity across the included studies (I<sup>2</sup> = 0%, <i>p</i> for Cochran’s Q = 0.52). In the subgroup analysis, no heterogeneity (<i>p</i> = 0.77) was identified in the effect of colchicine on stroke prevention between patients with recent acute (RR = 0.55, 95% CI: 0.15–2.05) or chronic stable (RR = 0.43, 95% CI: 0.21–0.89) coronary artery syndromes. In conclusion, we found that colchicine treatment decreases the stroke risk in patients with a history of atherosclerotic cardiovascular disease.https://www.mdpi.com/2077-0383/10/14/3110strokecolchicinecoronary artery diseaseprevention |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aristeidis H. Katsanos Lina Palaiodimou Christopher Price Marios Themistocleous Robin Lemmens Ioannis Michopoulos Marios K. Georgakis Christian Weimar Peter Kelly Georgios Tsivgoulis |
spellingShingle |
Aristeidis H. Katsanos Lina Palaiodimou Christopher Price Marios Themistocleous Robin Lemmens Ioannis Michopoulos Marios K. Georgakis Christian Weimar Peter Kelly Georgios Tsivgoulis An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery Disease Journal of Clinical Medicine stroke colchicine coronary artery disease prevention |
author_facet |
Aristeidis H. Katsanos Lina Palaiodimou Christopher Price Marios Themistocleous Robin Lemmens Ioannis Michopoulos Marios K. Georgakis Christian Weimar Peter Kelly Georgios Tsivgoulis |
author_sort |
Aristeidis H. Katsanos |
title |
An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery Disease |
title_short |
An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery Disease |
title_full |
An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery Disease |
title_fullStr |
An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery Disease |
title_full_unstemmed |
An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery Disease |
title_sort |
updated meta-analysis of rcts of colchicine for stroke prevention in patients with coronary artery disease |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-07-01 |
description |
Emerging evidence from randomized controlled clinical trials (RCTs) suggests that colchicine has cardiovascular benefits for patients with coronary disease, including benefits for stroke prevention. We performed an updated systematic review and meta-analysis of all RCTs reporting on stroke outcomes during the follow-up of patients with a history of cardiovascular disease randomized to colchicine treatment or control (placebo or usual care). We identified 6 RCTs including a total of 11,870 patients (mean age 63 years, 83% males) with a mean follow-up of 2 years. Colchicine treatment was associated with a lower risk of stroke during follow-up, compared to that of placebo or usual care (risk ratio = 0.49, 95% confidence interval: 0.31–0.80; <i>p</i> = 0.004), without heterogeneity across the included studies (I<sup>2</sup> = 0%, <i>p</i> for Cochran’s Q = 0.52). In the subgroup analysis, no heterogeneity (<i>p</i> = 0.77) was identified in the effect of colchicine on stroke prevention between patients with recent acute (RR = 0.55, 95% CI: 0.15–2.05) or chronic stable (RR = 0.43, 95% CI: 0.21–0.89) coronary artery syndromes. In conclusion, we found that colchicine treatment decreases the stroke risk in patients with a history of atherosclerotic cardiovascular disease. |
topic |
stroke colchicine coronary artery disease prevention |
url |
https://www.mdpi.com/2077-0383/10/14/3110 |
work_keys_str_mv |
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