Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients
Diego Novick,1 William Montgomery,2 Jaume Aguado,3 Xiaomei Peng,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Un...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2016-04-01
|
Series: | Neuropsychiatric Disease and Treatment |
Subjects: | |
Online Access: | https://www.dovepress.com/impact-of-anxiety-symptoms-on-outcomes-of-depression-an-observational--peer-reviewed-article-NDT |
id |
doaj-16f1b2e52b314808bd30af1d6b43360a |
---|---|
record_format |
Article |
spelling |
doaj-16f1b2e52b314808bd30af1d6b43360a2020-11-24T23:32:59ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212016-04-012016Issue 179580026368Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patientsNovick DMontgomery WAguado JPeng XMHaro JMDiego Novick,1 William Montgomery,2 Jaume Aguado,3 Xiaomei Peng,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly and Company, Indianapolis, IN, USA Objective: To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD) (n=714). Methods: The 17-item Hamilton Depression Scale (HAMD-17), overall severity, somatic symptoms, and quality of life (QOL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline. Results: Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723–0.951]). Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045–0.001]). Conclusion: In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression. Keywords: depression, anxiety, Asia, observational, outcomeshttps://www.dovepress.com/impact-of-anxiety-symptoms-on-outcomes-of-depression-an-observational--peer-reviewed-article-NDTDepressionanxietyAsiaobservationaloutcomes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Novick D Montgomery W Aguado J Peng XM Haro JM |
spellingShingle |
Novick D Montgomery W Aguado J Peng XM Haro JM Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients Neuropsychiatric Disease and Treatment Depression anxiety Asia observational outcomes |
author_facet |
Novick D Montgomery W Aguado J Peng XM Haro JM |
author_sort |
Novick D |
title |
Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients |
title_short |
Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients |
title_full |
Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients |
title_fullStr |
Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients |
title_full_unstemmed |
Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients |
title_sort |
impact of anxiety symptoms on outcomes of depression: an observational study in asian patients |
publisher |
Dove Medical Press |
series |
Neuropsychiatric Disease and Treatment |
issn |
1178-2021 |
publishDate |
2016-04-01 |
description |
Diego Novick,1 William Montgomery,2 Jaume Aguado,3 Xiaomei Peng,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly and Company, Indianapolis, IN, USA Objective: To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD) (n=714). Methods: The 17-item Hamilton Depression Scale (HAMD-17), overall severity, somatic symptoms, and quality of life (QOL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline. Results: Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723–0.951]). Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045–0.001]). Conclusion: In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression. Keywords: depression, anxiety, Asia, observational, outcomes |
topic |
Depression anxiety Asia observational outcomes |
url |
https://www.dovepress.com/impact-of-anxiety-symptoms-on-outcomes-of-depression-an-observational--peer-reviewed-article-NDT |
work_keys_str_mv |
AT novickd impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients AT montgomeryw impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients AT aguadoj impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients AT pengxm impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients AT harojm impactofanxietysymptomsonoutcomesofdepressionanobservationalstudyinasianpatients |
_version_ |
1725532400706912256 |