Hyponatremia and psychotropics
Psychotropic-induced hyponatremia is one of the most common electrolyte abnormalities seen in routine psychiatric practice and is especially common in elderly subjects. Recent evidence suggests that even mild hyponatremia is associated with several detrimental effects in elderly. However, practicing...
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doaj-16f3ebb0316b4dafa2f6a7cafa63121f2020-11-24T22:50:43ZengWolters Kluwer Medknow PublicationsJournal of Geriatric Mental Health2348-99952395-33222016-01-013210812210.4103/2348-9995.195604Hyponatremia and psychotropicsSwapnajeet SahooSandeep GroverPsychotropic-induced hyponatremia is one of the most common electrolyte abnormalities seen in routine psychiatric practice and is especially common in elderly subjects. Recent evidence suggests that even mild hyponatremia is associated with several detrimental effects in elderly. However, practicing clinicians often overlook hyponatremia due to lack of awareness about the incidence, presentation, and risk factors of psychotropic-induced hyponatremia. Available evidence suggests that all classes of psychotropics, i.e., antidepressants, antipsychotics, mood stabilizers, and sedative/hypnotics can lead to hyponatremia. Maximum evidence is available for antidepressant-associated hyponatremia. Various risk factors for hyponatremia include increasing age, female gender, low body weight, history of hyponatremia, low baseline sodium levels, summer season, initial phase of antidepressant use, early-onset psychiatric illnesses, longer duration of psychiatric disorder, prolonged admission, presence of comorbid medical conditions, concomitant use of diuretics, antihypertensives, and cytochrome P450 inhibitors. Awareness about this potentially life-threatening side effect and taking appropriate, timely steps can help in prevention of psychotropic-associated hyponatremia.http://www.jgmh.org/article.asp?issn=2348-9995;year=2016;volume=3;issue=2;spage=108;epage=122;aulast=SahooAntidepressantshyponatremiapsychotropics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Swapnajeet Sahoo Sandeep Grover |
spellingShingle |
Swapnajeet Sahoo Sandeep Grover Hyponatremia and psychotropics Journal of Geriatric Mental Health Antidepressants hyponatremia psychotropics |
author_facet |
Swapnajeet Sahoo Sandeep Grover |
author_sort |
Swapnajeet Sahoo |
title |
Hyponatremia and psychotropics |
title_short |
Hyponatremia and psychotropics |
title_full |
Hyponatremia and psychotropics |
title_fullStr |
Hyponatremia and psychotropics |
title_full_unstemmed |
Hyponatremia and psychotropics |
title_sort |
hyponatremia and psychotropics |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Geriatric Mental Health |
issn |
2348-9995 2395-3322 |
publishDate |
2016-01-01 |
description |
Psychotropic-induced hyponatremia is one of the most common electrolyte abnormalities seen in routine psychiatric practice and is especially common in elderly subjects. Recent evidence suggests that even mild hyponatremia is associated with several detrimental effects in elderly. However, practicing clinicians often overlook hyponatremia due to lack of awareness about the incidence, presentation, and risk factors of psychotropic-induced hyponatremia. Available evidence suggests that all classes of psychotropics, i.e., antidepressants, antipsychotics, mood stabilizers, and sedative/hypnotics can lead to hyponatremia. Maximum evidence is available for antidepressant-associated hyponatremia. Various risk factors for hyponatremia include increasing age, female gender, low body weight, history of hyponatremia, low baseline sodium levels, summer season, initial phase of antidepressant use, early-onset psychiatric illnesses, longer duration of psychiatric disorder, prolonged admission, presence of comorbid medical conditions, concomitant use of diuretics, antihypertensives, and cytochrome P450 inhibitors. Awareness about this potentially life-threatening side effect and taking appropriate, timely steps can help in prevention of psychotropic-associated hyponatremia. |
topic |
Antidepressants hyponatremia psychotropics |
url |
http://www.jgmh.org/article.asp?issn=2348-9995;year=2016;volume=3;issue=2;spage=108;epage=122;aulast=Sahoo |
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