| Summary: | Recent studies have shown that P-selectin promotes the early formation of atherosclerotic plaque. The aim of the present study was to evaluate whether the <i>SELP</i> gene single nucleotide polymorphisms (SNPs) are associated with presence of acute coronary syndrome (ACS) and with plasma P-selectin levels in a case-control association study. The sample size was estimated for a statistical power of 80%. We genotyped three <i>SELP</i> (<i>SELP</i> Ser290Asn, <i>SELP</i> Leu599Val, and <i>SELP</i> Thr715Pro) SNPs using 5’ exonuclease TaqMan assays in 625 patients with ACS and 700 healthy controls. The associations were evaluated with logistic regressions under the co-dominant, dominant, recessive, over-dominant and additive inheritance models. The genotype contribution to the plasma P-selectin levels was evaluated by a Student’s t-test. Under different models, the <i>SELP</i> Ser290Asn (OR = 0.59, <i>pC<sub>Co-</sub></i><sub>Dominant</sub> = 0.047; OR = 0.59, <i>pC</i><sub>Dominant</sub> = 0.014; OR = 0.58, <i>pC<sub>Over-</sub></i><sub>Dominant</sub> = 0.061, and OR = 0.62, <i>pC</i><sub>Additive</sub> = 0.015) and <i>SELP</i> Thr715Pro (OR = 0.61, <i>pC</i><sub>Dominant</sub> = 0.028; OR = 0.63, <i>pC<sub>Over-</sub></i><sub>Dominant</sub> = 0.044, and OR = 0.62, <i>pC</i><sub>Additive</sub> = 0.023) SNPs were associated with a lower risk of ACS. In addition, these SNPs were associated with low plasma P-selectin levels. In summary, this study established that the <i>SELP</i> Ser290Asn and <i>SELP</i> Thr715Pro SNPs are associated with a lower risk of developing ACS and with decreased P-selectin levels in plasma in a Mexican population.
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