The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population

The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population

Recent studies have shown that P-selectin promotes the early formation of atherosclerotic plaque. The aim of the present study was to evaluate whether the <i>SELP</i> gene single nucleotide polymorphisms (SNPs) are associated with presence of acute coronary syndrome (ACS) and with plasma...

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Main Authors: Gabriel Herrera-Maya, Gilberto Vargas-Alarcón, Oscar Pérez-Méndez, Rosalinda Posadas-Sánchez, Felipe Masso, Teresa Juárez-Cedillo, Galileo Escobedo, Andros Vázquez-Montero, José Manuel Fragoso
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
acute coronary syndrome
p-selectin
genetics
polymorphisms
susceptibility
Online Access:https://www.mdpi.com/2218-273X/10/2/270
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spelling doaj-170eccc802a34b4e994686b8f892b6292020-11-25T02:06:05ZengMDPI AGBiomolecules2218-273X2020-02-0110227010.3390/biom10020270biom10020270The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican PopulationGabriel Herrera-Maya0Gilberto Vargas-Alarcón1Oscar Pérez-Méndez2Rosalinda Posadas-Sánchez3Felipe Masso4Teresa Juárez-Cedillo5Galileo Escobedo6Andros Vázquez-Montero7José Manuel Fragoso8Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoLaboratory of Translational Medicine, UNAM-INC Research Unit, Instituto Nacional de Cardiología, Ignacio Chávez, Mexico City 14080, MexicoCommissioned of the Research Unit in Clinical Epidemiology, Hospital Regional No. 1, Dr. Carlos McGregor Sánchez Navarro, Instituto Mexicano del Seguro Social, Mexico City 14080, MexicoUnit of the Experimental Medicine, Hospital General de Mexico, Dr. Eduardo Liceaga, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoRecent studies have shown that P-selectin promotes the early formation of atherosclerotic plaque. The aim of the present study was to evaluate whether the <i>SELP</i> gene single nucleotide polymorphisms (SNPs) are associated with presence of acute coronary syndrome (ACS) and with plasma P-selectin levels in a case-control association study. The sample size was estimated for a statistical power of 80%. We genotyped three <i>SELP</i> (<i>SELP</i> Ser290Asn, <i>SELP</i> Leu599Val, and <i>SELP</i> Thr715Pro) SNPs using 5&#8217; exonuclease TaqMan assays in 625 patients with ACS and 700 healthy controls. The associations were evaluated with logistic regressions under the co-dominant, dominant, recessive, over-dominant and additive inheritance models. The genotype contribution to the plasma P-selectin levels was evaluated by a Student&#8217;s t-test. Under different models, the <i>SELP</i> Ser290Asn (OR = 0.59, <i>pC<sub>Co-</sub></i><sub>Dominant</sub> = 0.047; OR = 0.59, <i>pC</i><sub>Dominant</sub> = 0.014; OR = 0.58, <i>pC<sub>Over-</sub></i><sub>Dominant</sub> = 0.061, and OR = 0.62, <i>pC</i><sub>Additive</sub> = 0.015) and <i>SELP</i> Thr715Pro (OR = 0.61, <i>pC</i><sub>Dominant</sub> = 0.028; OR = 0.63, <i>pC<sub>Over-</sub></i><sub>Dominant</sub> = 0.044, and OR = 0.62, <i>pC</i><sub>Additive</sub> = 0.023) SNPs were associated with a lower risk of ACS. In addition, these SNPs were associated with low plasma P-selectin levels. In summary, this study established that the <i>SELP</i> Ser290Asn and <i>SELP</i> Thr715Pro SNPs are associated with a lower risk of developing ACS and with decreased P-selectin levels in plasma in a Mexican population.https://www.mdpi.com/2218-273X/10/2/270acute coronary syndromep-selectingeneticspolymorphismssusceptibility
collection DOAJ
language English
format Article
sources DOAJ
author Gabriel Herrera-Maya
Gilberto Vargas-Alarcón
Oscar Pérez-Méndez
Rosalinda Posadas-Sánchez
Felipe Masso
Teresa Juárez-Cedillo
Galileo Escobedo
Andros Vázquez-Montero
José Manuel Fragoso
spellingShingle Gabriel Herrera-Maya
Gilberto Vargas-Alarcón
Oscar Pérez-Méndez
Rosalinda Posadas-Sánchez
Felipe Masso
Teresa Juárez-Cedillo
Galileo Escobedo
Andros Vázquez-Montero
José Manuel Fragoso
The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population
Biomolecules
acute coronary syndrome
p-selectin
genetics
polymorphisms
susceptibility
author_facet Gabriel Herrera-Maya
Gilberto Vargas-Alarcón
Oscar Pérez-Méndez
Rosalinda Posadas-Sánchez
Felipe Masso
Teresa Juárez-Cedillo
Galileo Escobedo
Andros Vázquez-Montero
José Manuel Fragoso
author_sort Gabriel Herrera-Maya
title The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population
title_short The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population
title_full The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population
title_fullStr The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population
title_full_unstemmed The Ser290Asn and Thr715Pro Polymorphisms of the <i>SELP</i> Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population
title_sort ser290asn and thr715pro polymorphisms of the <i>selp</i> gene are associated with a lower risk of developing acute coronary syndrome and low soluble p-selectin levels in a mexican population
publisher MDPI AG
series Biomolecules
issn 2218-273X
publishDate 2020-02-01
description Recent studies have shown that P-selectin promotes the early formation of atherosclerotic plaque. The aim of the present study was to evaluate whether the <i>SELP</i> gene single nucleotide polymorphisms (SNPs) are associated with presence of acute coronary syndrome (ACS) and with plasma P-selectin levels in a case-control association study. The sample size was estimated for a statistical power of 80%. We genotyped three <i>SELP</i> (<i>SELP</i> Ser290Asn, <i>SELP</i> Leu599Val, and <i>SELP</i> Thr715Pro) SNPs using 5&#8217; exonuclease TaqMan assays in 625 patients with ACS and 700 healthy controls. The associations were evaluated with logistic regressions under the co-dominant, dominant, recessive, over-dominant and additive inheritance models. The genotype contribution to the plasma P-selectin levels was evaluated by a Student&#8217;s t-test. Under different models, the <i>SELP</i> Ser290Asn (OR = 0.59, <i>pC<sub>Co-</sub></i><sub>Dominant</sub> = 0.047; OR = 0.59, <i>pC</i><sub>Dominant</sub> = 0.014; OR = 0.58, <i>pC<sub>Over-</sub></i><sub>Dominant</sub> = 0.061, and OR = 0.62, <i>pC</i><sub>Additive</sub> = 0.015) and <i>SELP</i> Thr715Pro (OR = 0.61, <i>pC</i><sub>Dominant</sub> = 0.028; OR = 0.63, <i>pC<sub>Over-</sub></i><sub>Dominant</sub> = 0.044, and OR = 0.62, <i>pC</i><sub>Additive</sub> = 0.023) SNPs were associated with a lower risk of ACS. In addition, these SNPs were associated with low plasma P-selectin levels. In summary, this study established that the <i>SELP</i> Ser290Asn and <i>SELP</i> Thr715Pro SNPs are associated with a lower risk of developing ACS and with decreased P-selectin levels in plasma in a Mexican population.
topic acute coronary syndrome
p-selectin
genetics
polymorphisms
susceptibility
url https://www.mdpi.com/2218-273X/10/2/270
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