<it>Decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>polymorphisms and development of COPD in a general population
<p>Abstract</p> <p>Background</p> <p>Decorin, an extracellular matrix (ECM) proteoglycan, and <it>TGF-β</it><sub><it>1 </it></sub>are both involved in lung ECM turnover. Decorin and <it>TGF-β</it><sub><it>1 <...
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doaj-173187f794854cc5ac2fb16f0b66a5722020-11-25T01:11:00ZengBMCRespiratory Research1465-99212006-06-01718910.1186/1465-9921-7-89<it>Decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>polymorphisms and development of COPD in a general populationNolte Ilja MBruinenberg MarcelVonk Judith MPostma Dirkje Svan Diemen Cleo CBoezen H Marike<p>Abstract</p> <p>Background</p> <p>Decorin, an extracellular matrix (ECM) proteoglycan, and <it>TGF-β</it><sub><it>1 </it></sub>are both involved in lung ECM turnover. Decorin and <it>TGF-β</it><sub><it>1 </it></sub>expression are decreased respectively increased in COPD lung tissue. Interestingly, they act as each other's feedback regulator. We investigated whether single nucleotide polymorphisms (SNPs) in <it>decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>underlie accelerated decline in FEV<sub><it>1 </it></sub>and development of COPD in the general population.</p> <p>Methods</p> <p>We genotyped 1390 subjects from the Vlagtwedde/Vlaardingen cohort. Lung function was measured every 3 years for a period of 25 years. We tested whether five SNPs in <it>decorin </it>(3'UTR and four intron SNPs) and three SNPs in <it>TGF-β</it><sub><it>1 </it></sub>(3'UTR rs6957, C-509T rs1800469 and Leu10Pro rs1982073), and their haplotypes, were associated with COPD (last survey GOLD stage = II). Linear mixed effects models were used to analyze genotype associations with FEV<sub>1 </sub>decline.</p> <p>Results</p> <p>We found a significantly higher prevalence of carriers of the minor allele of the <it>TGF-β</it><sub><it>1 </it></sub>rs6957 SNP (p = 0.001) in subjects with COPD. Additionally, we found a significantly lower prevalence of the haplotype with the major allele of rs6957 and minor alleles for rs1800469 and rs1982073 SNPs in <it>TGF-β</it><sub><it>1 </it></sub>in subjects with COPD (p = 0.030), indicating that this association is due to the rs6957 SNP. <it>TGF-β</it><sub><it>1 </it></sub>SNPs were not associated with FEV<sub>1 </sub>decline. SNPs in <it>decorin</it>, and haplotypes constructed of both <it>TGF-β</it><sub><it>1 </it></sub>and <it>decorin </it>SNPs were not associated with development of COPD or with FEV<sub>1 </sub>decline.</p> <p>Conclusion</p> <p>Our study shows for the first time that SNPs in <it>decorin </it>on its own or in interaction with SNPs in <it>TGF-β</it><sub><it>1 </it></sub>do not underlie the disturbed balance in expression between these genes in COPD. <it>TGF-β</it><sub><it>1 </it></sub>SNPs are associated with COPD, yet not with accelerated FEV<sub>1 </sub>decline in the general population.</p> http://respiratory-research.com/content/7/1/89 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nolte Ilja M Bruinenberg Marcel Vonk Judith M Postma Dirkje S van Diemen Cleo C Boezen H Marike |
spellingShingle |
Nolte Ilja M Bruinenberg Marcel Vonk Judith M Postma Dirkje S van Diemen Cleo C Boezen H Marike <it>Decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>polymorphisms and development of COPD in a general population Respiratory Research |
author_facet |
Nolte Ilja M Bruinenberg Marcel Vonk Judith M Postma Dirkje S van Diemen Cleo C Boezen H Marike |
author_sort |
Nolte Ilja M |
title |
<it>Decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>polymorphisms and development of COPD in a general population |
title_short |
<it>Decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>polymorphisms and development of COPD in a general population |
title_full |
<it>Decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>polymorphisms and development of COPD in a general population |
title_fullStr |
<it>Decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>polymorphisms and development of COPD in a general population |
title_full_unstemmed |
<it>Decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>polymorphisms and development of COPD in a general population |
title_sort |
<it>decorin </it>and <it>tgf-β</it><sub><it>1 </it></sub>polymorphisms and development of copd in a general population |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-9921 |
publishDate |
2006-06-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Decorin, an extracellular matrix (ECM) proteoglycan, and <it>TGF-β</it><sub><it>1 </it></sub>are both involved in lung ECM turnover. Decorin and <it>TGF-β</it><sub><it>1 </it></sub>expression are decreased respectively increased in COPD lung tissue. Interestingly, they act as each other's feedback regulator. We investigated whether single nucleotide polymorphisms (SNPs) in <it>decorin </it>and <it>TGF-β</it><sub><it>1 </it></sub>underlie accelerated decline in FEV<sub><it>1 </it></sub>and development of COPD in the general population.</p> <p>Methods</p> <p>We genotyped 1390 subjects from the Vlagtwedde/Vlaardingen cohort. Lung function was measured every 3 years for a period of 25 years. We tested whether five SNPs in <it>decorin </it>(3'UTR and four intron SNPs) and three SNPs in <it>TGF-β</it><sub><it>1 </it></sub>(3'UTR rs6957, C-509T rs1800469 and Leu10Pro rs1982073), and their haplotypes, were associated with COPD (last survey GOLD stage = II). Linear mixed effects models were used to analyze genotype associations with FEV<sub>1 </sub>decline.</p> <p>Results</p> <p>We found a significantly higher prevalence of carriers of the minor allele of the <it>TGF-β</it><sub><it>1 </it></sub>rs6957 SNP (p = 0.001) in subjects with COPD. Additionally, we found a significantly lower prevalence of the haplotype with the major allele of rs6957 and minor alleles for rs1800469 and rs1982073 SNPs in <it>TGF-β</it><sub><it>1 </it></sub>in subjects with COPD (p = 0.030), indicating that this association is due to the rs6957 SNP. <it>TGF-β</it><sub><it>1 </it></sub>SNPs were not associated with FEV<sub>1 </sub>decline. SNPs in <it>decorin</it>, and haplotypes constructed of both <it>TGF-β</it><sub><it>1 </it></sub>and <it>decorin </it>SNPs were not associated with development of COPD or with FEV<sub>1 </sub>decline.</p> <p>Conclusion</p> <p>Our study shows for the first time that SNPs in <it>decorin </it>on its own or in interaction with SNPs in <it>TGF-β</it><sub><it>1 </it></sub>do not underlie the disturbed balance in expression between these genes in COPD. <it>TGF-β</it><sub><it>1 </it></sub>SNPs are associated with COPD, yet not with accelerated FEV<sub>1 </sub>decline in the general population.</p> |
url |
http://respiratory-research.com/content/7/1/89 |
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