Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing
Continuous glucose monitoring (CGM) is crucial in order to avoid complications caused by change in blood glucose for patients suffering from diabetes mellitus. The long-term consequences of high blood glucose levels include damage to the heart, eyes, kidneys, nerves and other organs, among others,...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-12-01
|
Series: | Biosensors |
Subjects: | |
Online Access: | http://www.mdpi.com/2079-6374/3/4/400 |
id |
doaj-1738ba2602404bacb1dcaaca5768b60e |
---|---|
record_format |
Article |
spelling |
doaj-1738ba2602404bacb1dcaaca5768b60e2020-11-24T23:34:06ZengMDPI AGBiosensors2079-63742013-12-013440041810.3390/bios3040400bios3040400Recent Advances in Fluorescent Arylboronic Acids for Glucose SensingJon Stefan Hansen0Jørn Bolstad Christensen1Department of Chemistry, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, DenmarkDepartment of Chemistry, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, DenmarkContinuous glucose monitoring (CGM) is crucial in order to avoid complications caused by change in blood glucose for patients suffering from diabetes mellitus. The long-term consequences of high blood glucose levels include damage to the heart, eyes, kidneys, nerves and other organs, among others, caused by malign glycation of vital protein structures. Fluorescent monitors based on arylboronic acids are promising candidates for optical CGM, since arylboronic acids are capable of forming arylboronate esters with 1,2-cis-diols or 1,3-diols fast and reversibly, even in aqueous solution. These properties enable arylboronic acid dyes to provide immediate information of glucose concentrations. Thus, the replacement of the commonly applied semi-invasive and non-invasive techniques relying on glucose binding proteins, such as concanavalin A, or enzymes, such as glucose oxidase, glucose dehydrogenase and hexokinases/glucokinases, might be possible. The recent progress in the development of fluorescent arylboronic acid dyes will be emphasized in this review.http://www.mdpi.com/2079-6374/3/4/400continuous glucose monitoringarylboronic acidsfluorescenceselectivityimmobilizationdiabetes mellitus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jon Stefan Hansen Jørn Bolstad Christensen |
spellingShingle |
Jon Stefan Hansen Jørn Bolstad Christensen Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing Biosensors continuous glucose monitoring arylboronic acids fluorescence selectivity immobilization diabetes mellitus |
author_facet |
Jon Stefan Hansen Jørn Bolstad Christensen |
author_sort |
Jon Stefan Hansen |
title |
Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing |
title_short |
Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing |
title_full |
Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing |
title_fullStr |
Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing |
title_full_unstemmed |
Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing |
title_sort |
recent advances in fluorescent arylboronic acids for glucose sensing |
publisher |
MDPI AG |
series |
Biosensors |
issn |
2079-6374 |
publishDate |
2013-12-01 |
description |
Continuous glucose monitoring (CGM) is crucial in order to avoid complications caused by change in blood glucose for patients suffering from diabetes mellitus. The long-term consequences of high blood glucose levels include damage to the heart, eyes, kidneys, nerves and other organs, among others, caused by malign glycation of vital protein structures. Fluorescent monitors based on arylboronic acids are promising candidates for optical CGM, since arylboronic acids are capable of forming arylboronate esters with 1,2-cis-diols or 1,3-diols fast and reversibly, even in aqueous solution. These properties enable arylboronic acid dyes to provide immediate information of glucose concentrations. Thus, the replacement of the commonly applied semi-invasive and non-invasive techniques relying on glucose binding proteins, such as concanavalin A, or enzymes, such as glucose oxidase, glucose dehydrogenase and hexokinases/glucokinases, might be possible. The recent progress in the development of fluorescent arylboronic acid dyes will be emphasized in this review. |
topic |
continuous glucose monitoring arylboronic acids fluorescence selectivity immobilization diabetes mellitus |
url |
http://www.mdpi.com/2079-6374/3/4/400 |
work_keys_str_mv |
AT jonstefanhansen recentadvancesinfluorescentarylboronicacidsforglucosesensing AT jørnbolstadchristensen recentadvancesinfluorescentarylboronicacidsforglucosesensing |
_version_ |
1725529589120237568 |