Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol
Abstract Performing functional magnetic resonance imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being scanned. Head motion represents a significant confound in fMRI connectivity analyses. One approach to limit motion has been to use shorter MRI protocol...
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2020-12-01
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doaj-17456881c17f4329826410a4bae7873a2020-12-20T12:28:22ZengNature Publishing GroupScientific Reports2045-23222020-12-0110111010.1038/s41598-020-78885-zLow-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocolCorey Horien0Scuddy Fontenelle1Kohrissa Joseph2Nicole Powell3Chaela Nutor4Diogo Fortes5Maureen Butler6Kelly Powell7Deanna Macris8Kangjoo Lee9Abigail S. Greene10James C. McPartland11Fred R. Volkmar12Dustin Scheinost13Katarzyna Chawarska14R. Todd Constable15Interdepartmental Neuroscience Program, Yale School of MedicineYale Child Study CenterYale Child Study CenterYale Child Study CenterYale Child Study CenterYale Child Study CenterYale Child Study CenterYale Child Study CenterYale Child Study CenterDepartment of Radiology and Biomedical Imaging, Yale School of MedicineInterdepartmental Neuroscience Program, Yale School of MedicineYale Child Study CenterYale Child Study CenterInterdepartmental Neuroscience Program, Yale School of MedicineYale Child Study CenterInterdepartmental Neuroscience Program, Yale School of MedicineAbstract Performing functional magnetic resonance imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being scanned. Head motion represents a significant confound in fMRI connectivity analyses. One approach to limit motion has been to use shorter MRI protocols, though this reduces the reliability of results. Hence, there is a need to implement methods to achieve high-quality, low-motion data while not sacrificing data quantity. Here we show that by using a mock scan protocol prior to a scan, in conjunction with other in-scan steps (weighted blanket and incentive system), it is possible to achieve low-motion fMRI data in pediatric participants (age range: 7–17 years old) undergoing a 60 min MRI session. We also observe that motion is low during the MRI protocol in a separate replication group of participants, including some with autism spectrum disorder. Collectively, the results indicate it is possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-quality data, thus potentially allowing more reliable fMRI findings.https://doi.org/10.1038/s41598-020-78885-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Corey Horien Scuddy Fontenelle Kohrissa Joseph Nicole Powell Chaela Nutor Diogo Fortes Maureen Butler Kelly Powell Deanna Macris Kangjoo Lee Abigail S. Greene James C. McPartland Fred R. Volkmar Dustin Scheinost Katarzyna Chawarska R. Todd Constable |
spellingShingle |
Corey Horien Scuddy Fontenelle Kohrissa Joseph Nicole Powell Chaela Nutor Diogo Fortes Maureen Butler Kelly Powell Deanna Macris Kangjoo Lee Abigail S. Greene James C. McPartland Fred R. Volkmar Dustin Scheinost Katarzyna Chawarska R. Todd Constable Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol Scientific Reports |
author_facet |
Corey Horien Scuddy Fontenelle Kohrissa Joseph Nicole Powell Chaela Nutor Diogo Fortes Maureen Butler Kelly Powell Deanna Macris Kangjoo Lee Abigail S. Greene James C. McPartland Fred R. Volkmar Dustin Scheinost Katarzyna Chawarska R. Todd Constable |
author_sort |
Corey Horien |
title |
Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol |
title_short |
Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol |
title_full |
Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol |
title_fullStr |
Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol |
title_full_unstemmed |
Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol |
title_sort |
low-motion fmri data can be obtained in pediatric participants undergoing a 60-minute scan protocol |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-12-01 |
description |
Abstract Performing functional magnetic resonance imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being scanned. Head motion represents a significant confound in fMRI connectivity analyses. One approach to limit motion has been to use shorter MRI protocols, though this reduces the reliability of results. Hence, there is a need to implement methods to achieve high-quality, low-motion data while not sacrificing data quantity. Here we show that by using a mock scan protocol prior to a scan, in conjunction with other in-scan steps (weighted blanket and incentive system), it is possible to achieve low-motion fMRI data in pediatric participants (age range: 7–17 years old) undergoing a 60 min MRI session. We also observe that motion is low during the MRI protocol in a separate replication group of participants, including some with autism spectrum disorder. Collectively, the results indicate it is possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-quality data, thus potentially allowing more reliable fMRI findings. |
url |
https://doi.org/10.1038/s41598-020-78885-z |
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