Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101)
Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate (AS101) is the most important synthetic Te compound from the standpoint of its biological activity. It is a potent immunomodulator with a variety of potential therapeutic applications and antitumoral action in several preclinical and clinical...
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doaj-174f213c40984af78cd1fa990000e8292020-11-24T23:53:23ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-02-011523287329810.3390/ijms15023287ijms15023287Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101)M. Pilar Vázquez-Tato0Alberto Mena-Menéndez1Xesús Feás2Julio A. Seijas3Department of Organic Chemistry, Faculty of Science, University of Santiago de Compostela, E-27002 Lugo, SpainDepartment of Organic Chemistry, Faculty of Science, University of Santiago de Compostela, E-27002 Lugo, SpainDepartment of Organic Chemistry, Faculty of Science, University of Santiago de Compostela, E-27002 Lugo, SpainDepartment of Organic Chemistry, Faculty of Science, University of Santiago de Compostela, E-27002 Lugo, SpainAmmonium trichloro[1,2-ethanediolato-O,O']-tellurate (AS101) is the most important synthetic Te compound from the standpoint of its biological activity. It is a potent immunomodulator with a variety of potential therapeutic applications and antitumoral action in several preclinical and clinical studies. An experimental design has been used to develop and optimize a novel microwave-assisted synthesis (MAOS) of the AS101. In comparison to the results observed in the literature, refluxing Te(IV) chloride and ethylene glycol in acetonitrile (Method A), or by refluxing Te(IV) chloride and ammonium chloride in ethylene glycol (Method B), it was found that the developed methods in the present work are an effective alternative, because although performance slightly decreases compared to conventional procedures (75% vs. 79% by Method A, and 45% vs. 51% by Method B), reaction times decreased from 4 h to 30 min and from 4 h to 10 min, by Methods A and B respectively. MAOS is proving to be of value in the rapid synthesis of compounds with new and improved biological activities, specially based on the benefit of its shorter reaction times.http://www.mdpi.com/1422-0067/15/2/3287TelluriumAS101ammonium trichloro[1,2-ethanediolato-O,O']-telluratemicrowave irradiationantitumoral |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Pilar Vázquez-Tato Alberto Mena-Menéndez Xesús Feás Julio A. Seijas |
spellingShingle |
M. Pilar Vázquez-Tato Alberto Mena-Menéndez Xesús Feás Julio A. Seijas Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101) International Journal of Molecular Sciences Tellurium AS101 ammonium trichloro[1,2-ethanediolato-O,O']-tellurate microwave irradiation antitumoral |
author_facet |
M. Pilar Vázquez-Tato Alberto Mena-Menéndez Xesús Feás Julio A. Seijas |
author_sort |
M. Pilar Vázquez-Tato |
title |
Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101) |
title_short |
Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101) |
title_full |
Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101) |
title_fullStr |
Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101) |
title_full_unstemmed |
Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101) |
title_sort |
novel microwave-assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro(dioxoethylene-o,o')tellurate (as101) |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2014-02-01 |
description |
Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate (AS101) is the most important synthetic Te compound from the standpoint of its biological activity. It is a potent immunomodulator with a variety of potential therapeutic applications and antitumoral action in several preclinical and clinical studies. An experimental design has been used to develop and optimize a novel microwave-assisted synthesis (MAOS) of the AS101. In comparison to the results observed in the literature, refluxing Te(IV) chloride and ethylene glycol in acetonitrile (Method A), or by refluxing Te(IV) chloride and ammonium chloride in ethylene glycol (Method B), it was found that the developed methods in the present work are an effective alternative, because although performance slightly decreases compared to conventional procedures (75% vs. 79% by Method A, and 45% vs. 51% by Method B), reaction times decreased from 4 h to 30 min and from 4 h to 10 min, by Methods A and B respectively. MAOS is proving to be of value in the rapid synthesis of compounds with new and improved biological activities, specially based on the benefit of its shorter reaction times. |
topic |
Tellurium AS101 ammonium trichloro[1,2-ethanediolato-O,O']-tellurate microwave irradiation antitumoral |
url |
http://www.mdpi.com/1422-0067/15/2/3287 |
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