Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice
Exercise has been recommended as an important strategy to impro ve glucose metabolism in obesity. Adipose tissue fibrosis is associated with inflammati on and is implicated in glucose metabolism disturbance and insulin resistance in obesit y. However, the effect of exercise on the progression of adi...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Bioscientifica
2021-04-01
|
Series: | Endocrine Connections |
Subjects: | |
Online Access: | https://ec.bioscientifica.com/view/journals/ec/10/3/EC-20-0643.xml |
id |
doaj-174fd46472ac4ec1b5a1a24807f93682 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liangming Li Yuan Wei Chunlu Fang Shujing Liu Fu Zhou Ge Zhao Yaping Li Yuan Luo Ziyi Guo Weiqun Lin Wenqi Yang |
spellingShingle |
Liangming Li Yuan Wei Chunlu Fang Shujing Liu Fu Zhou Ge Zhao Yaping Li Yuan Luo Ziyi Guo Weiqun Lin Wenqi Yang Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice Endocrine Connections exercise adipose tissue fibrosis glucose metabolism pparγ inflammation |
author_facet |
Liangming Li Yuan Wei Chunlu Fang Shujing Liu Fu Zhou Ge Zhao Yaping Li Yuan Luo Ziyi Guo Weiqun Lin Wenqi Yang |
author_sort |
Liangming Li |
title |
Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice |
title_short |
Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice |
title_full |
Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice |
title_fullStr |
Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice |
title_full_unstemmed |
Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice |
title_sort |
exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2021-04-01 |
description |
Exercise has been recommended as an important strategy to impro ve glucose metabolism in obesity. Adipose tissue fibrosis is associated with inflammati on and is implicated in glucose metabolism disturbance and insulin resistance in obesit y. However, the effect of exercise on the progression of adipose tissue fibrosis is sti ll unknown. The aim of the present study was to investigate whether exercise retarded the progression of adipose tissue fibrosis and ameliorated glucose homeostasis in diet-indu ced obese mice. To do so, obesity and adipose tissue fibrosis in mice were induced by high-fat diet feeding for 12 weeks and the mice subsequently received high-fat diet and e xercise intervention for another 12 weeks. Exercise alleviated high-fat diet-induced glucose intolerance and insulin resistance. Continued high-fat diet feeding exacerbated collagen deposition and further increased fibrosis-related gene expression in adipose ti ssue. Exercise attenuated or reversed these changes. Additionally, PPARγ, which has been shown to inhibit adipose tissue fibrosis, was observed to be increased following exercise . Moreover, exercise decreased the expression of HIF-1α in adipose fibrosis, and adipose tissue inflammation was inhibited. In conclusion, our data indicate that exercise a ttenuates and even reverses the progression of adipose tissue fibrosis, providing a plausibl e mechanism for its beneficial effects on glucose metabolism in obesity. |
topic |
exercise adipose tissue fibrosis glucose metabolism pparγ inflammation |
url |
https://ec.bioscientifica.com/view/journals/ec/10/3/EC-20-0643.xml |
work_keys_str_mv |
AT liangmingli exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT yuanwei exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT chunlufang exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT shujingliu exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT fuzhou exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT gezhao exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT yapingli exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT yuanluo exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT ziyiguo exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT weiqunlin exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice AT wenqiyang exerciseretardsongoingadiposetissuefibrosisindietinducedobesemice |
_version_ |
1721536039523188736 |
spelling |
doaj-174fd46472ac4ec1b5a1a24807f936822021-04-07T11:37:11ZengBioscientificaEndocrine Connections2049-36142049-36142021-04-01103325335https://doi.org/10.1530/EC-20-0643Exercise retards ongoing adipose tissue fibrosis in diet-induced obese miceLiangming Li0Yuan Wei1Chunlu Fang2Shujing Liu3Fu Zhou4Ge Zhao5Yaping Li6Yuan Luo7Ziyi Guo8Weiqun Lin9Wenqi Yang10Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China; Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China; Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China; Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China; Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, ChinaKey Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, ChinaKey Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, ChinaKey Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, ChinaKey Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, ChinaDepartment of Clinical Nutrition, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, ChinaCenter for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China; Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China Exercise has been recommended as an important strategy to impro ve glucose metabolism in obesity. Adipose tissue fibrosis is associated with inflammati on and is implicated in glucose metabolism disturbance and insulin resistance in obesit y. However, the effect of exercise on the progression of adipose tissue fibrosis is sti ll unknown. The aim of the present study was to investigate whether exercise retarded the progression of adipose tissue fibrosis and ameliorated glucose homeostasis in diet-indu ced obese mice. To do so, obesity and adipose tissue fibrosis in mice were induced by high-fat diet feeding for 12 weeks and the mice subsequently received high-fat diet and e xercise intervention for another 12 weeks. Exercise alleviated high-fat diet-induced glucose intolerance and insulin resistance. Continued high-fat diet feeding exacerbated collagen deposition and further increased fibrosis-related gene expression in adipose ti ssue. Exercise attenuated or reversed these changes. Additionally, PPARγ, which has been shown to inhibit adipose tissue fibrosis, was observed to be increased following exercise . Moreover, exercise decreased the expression of HIF-1α in adipose fibrosis, and adipose tissue inflammation was inhibited. In conclusion, our data indicate that exercise a ttenuates and even reverses the progression of adipose tissue fibrosis, providing a plausibl e mechanism for its beneficial effects on glucose metabolism in obesity.https://ec.bioscientifica.com/view/journals/ec/10/3/EC-20-0643.xmlexerciseadipose tissue fibrosisglucose metabolismpparγinflammation |