Afferent Projections to Area Prostriata of the Mouse
Area prostriata plays important roles in fast detection and analysis of peripheral visual information. It remains unclear whether the prostriata directly receives and integrates information from other modalities. To gain insight into this issue, we investigated brain-wide afferent projections to mou...
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doaj-174fdfe2f61c409c8ff69d23e758fe942020-12-08T08:40:17ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292020-11-011410.3389/fnana.2020.605021605021Afferent Projections to Area Prostriata of the MouseJin-Meng Hu0Chang-Hui Chen1Sheng-Qiang Chen2Song-Lin Ding3Song-Lin Ding4Key Laboratory of Neuroscience, School of Basic Medical Sciences, Institute of Neuroscience, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Institute of Neuroscience, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Institute of Neuroscience, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Neuroscience, School of Basic Medical Sciences, Institute of Neuroscience, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaAllen Institute for Brain Science, Seattle, WA, United StatesArea prostriata plays important roles in fast detection and analysis of peripheral visual information. It remains unclear whether the prostriata directly receives and integrates information from other modalities. To gain insight into this issue, we investigated brain-wide afferent projections to mouse prostriata. We find convergent projections to layer 1 of the prostriata from primary and association visual and auditory cortices; retrosplenial, lateral entorhinal, and anterior cingulate cortices; subiculum; presubiculum; and anterior thalamic nuclei. Innervation of layers 2–3 of the prostriata mainly originates from the presubiculum (including postsubiculum) and anterior midline thalamic region. Layer 5 of the prostriata mainly receives its inputs from medial entorhinal, granular retrosplenial, and medial orbitofrontal cortices and anteromedial thalamic nucleus while layer 6 gets its major inputs from ectorhinal, postrhinal, and agranular retrosplenial cortices. The claustrum, locus coeruleus, and basal forebrain provide relatively diffuse innervation to the prostriata. Moreover, Cre-dependent tracing in cortical areas reveals that the cells of origin of the prostriata inputs are located in layers 2–4 and 5 of the neocortical areas, layers 2 and 5 of the medial entorhinal cortex, and layer 5 of the retrosplenial cortex. These results indicate that the prostriata is a unique region where primary and association visual and auditory inputs directly integrate with many limbic inputs.https://www.frontiersin.org/articles/10.3389/fnana.2020.605021/fullvisual cortexretrosplenial cortexauditory areaentorhinal cortexclaustrumconnecticity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jin-Meng Hu Chang-Hui Chen Sheng-Qiang Chen Song-Lin Ding Song-Lin Ding |
spellingShingle |
Jin-Meng Hu Chang-Hui Chen Sheng-Qiang Chen Song-Lin Ding Song-Lin Ding Afferent Projections to Area Prostriata of the Mouse Frontiers in Neuroanatomy visual cortex retrosplenial cortex auditory area entorhinal cortex claustrum connecticity |
author_facet |
Jin-Meng Hu Chang-Hui Chen Sheng-Qiang Chen Song-Lin Ding Song-Lin Ding |
author_sort |
Jin-Meng Hu |
title |
Afferent Projections to Area Prostriata of the Mouse |
title_short |
Afferent Projections to Area Prostriata of the Mouse |
title_full |
Afferent Projections to Area Prostriata of the Mouse |
title_fullStr |
Afferent Projections to Area Prostriata of the Mouse |
title_full_unstemmed |
Afferent Projections to Area Prostriata of the Mouse |
title_sort |
afferent projections to area prostriata of the mouse |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroanatomy |
issn |
1662-5129 |
publishDate |
2020-11-01 |
description |
Area prostriata plays important roles in fast detection and analysis of peripheral visual information. It remains unclear whether the prostriata directly receives and integrates information from other modalities. To gain insight into this issue, we investigated brain-wide afferent projections to mouse prostriata. We find convergent projections to layer 1 of the prostriata from primary and association visual and auditory cortices; retrosplenial, lateral entorhinal, and anterior cingulate cortices; subiculum; presubiculum; and anterior thalamic nuclei. Innervation of layers 2–3 of the prostriata mainly originates from the presubiculum (including postsubiculum) and anterior midline thalamic region. Layer 5 of the prostriata mainly receives its inputs from medial entorhinal, granular retrosplenial, and medial orbitofrontal cortices and anteromedial thalamic nucleus while layer 6 gets its major inputs from ectorhinal, postrhinal, and agranular retrosplenial cortices. The claustrum, locus coeruleus, and basal forebrain provide relatively diffuse innervation to the prostriata. Moreover, Cre-dependent tracing in cortical areas reveals that the cells of origin of the prostriata inputs are located in layers 2–4 and 5 of the neocortical areas, layers 2 and 5 of the medial entorhinal cortex, and layer 5 of the retrosplenial cortex. These results indicate that the prostriata is a unique region where primary and association visual and auditory inputs directly integrate with many limbic inputs. |
topic |
visual cortex retrosplenial cortex auditory area entorhinal cortex claustrum connecticity |
url |
https://www.frontiersin.org/articles/10.3389/fnana.2020.605021/full |
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