CDK6 inhibits white to beige fat transition by suppressing RUNX1

Beige adipocytes can arise from transdifferentiation of mature white adipocytes. Here the authors identify CDK6 as a key molecule involved in the white-to-beige adipocyte transdifferentiation and, therefore, as a regulator of organismal energy homeostasis in mice.

Bibliographic Details
Main Authors:	Xiaoli Hou, Yongzhao Zhang, Wei Li, Alexander J. Hu, Chi Luo, Wenhui Zhou, Jamie K. Hu, Stefano G. Daniele, Jinfeng Wang, Jinghao Sheng, Yongsheng Fan, Andrew S. Greenberg, Stephen R. Farmer, Miaofen G. Hu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03451-1

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spelling	doaj-17531b3802bd4bc69983bb653e2b2d972021-05-11T09:50:59ZengNature Publishing GroupNature Communications2041-17232018-03-019111410.1038/s41467-018-03451-1CDK6 inhibits white to beige fat transition by suppressing RUNX1Xiaoli Hou0Yongzhao Zhang1Wei Li2Alexander J. Hu3Chi Luo4Wenhui Zhou5Jamie K. Hu6Stefano G. Daniele7Jinfeng Wang8Jinghao Sheng9Yongsheng Fan10Andrew S. Greenberg11Stephen R. Farmer12Miaofen G. Hu13Molecular Oncology Research Institute, Tufts Medical CenterMolecular Oncology Research Institute, Tufts Medical CenterMolecular Oncology Research Institute, Tufts Medical CenterMolecular Oncology Research Institute, Tufts Medical CenterDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical SchoolMolecular Oncology Research Institute, Tufts Medical CenterMolecular Oncology Research Institute, Tufts Medical CenterYale School of Medicine, MD program for Jamie K. Hu, MD-PhD Program for Stefano G. DanieleMolecular Oncology Research Institute, Tufts Medical CenterMolecular Oncology Research Institute, Tufts Medical CenterZhejiang Chinese Medical University, Center for Analysis and TestingObesity and Metabolism Laboratory, JM-USDA Human Nutrition Research CenterBoston University School of Medicine, Department of BiochemistryMolecular Oncology Research Institute, Tufts Medical CenterBeige adipocytes can arise from transdifferentiation of mature white adipocytes. Here the authors identify CDK6 as a key molecule involved in the white-to-beige adipocyte transdifferentiation and, therefore, as a regulator of organismal energy homeostasis in mice.https://doi.org/10.1038/s41467-018-03451-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiaoli Hou Yongzhao Zhang Wei Li Alexander J. Hu Chi Luo Wenhui Zhou Jamie K. Hu Stefano G. Daniele Jinfeng Wang Jinghao Sheng Yongsheng Fan Andrew S. Greenberg Stephen R. Farmer Miaofen G. Hu
spellingShingle	Xiaoli Hou Yongzhao Zhang Wei Li Alexander J. Hu Chi Luo Wenhui Zhou Jamie K. Hu Stefano G. Daniele Jinfeng Wang Jinghao Sheng Yongsheng Fan Andrew S. Greenberg Stephen R. Farmer Miaofen G. Hu CDK6 inhibits white to beige fat transition by suppressing RUNX1 Nature Communications
author_facet	Xiaoli Hou Yongzhao Zhang Wei Li Alexander J. Hu Chi Luo Wenhui Zhou Jamie K. Hu Stefano G. Daniele Jinfeng Wang Jinghao Sheng Yongsheng Fan Andrew S. Greenberg Stephen R. Farmer Miaofen G. Hu
author_sort	Xiaoli Hou
title	CDK6 inhibits white to beige fat transition by suppressing RUNX1
title_short	CDK6 inhibits white to beige fat transition by suppressing RUNX1
title_full	CDK6 inhibits white to beige fat transition by suppressing RUNX1
title_fullStr	CDK6 inhibits white to beige fat transition by suppressing RUNX1
title_full_unstemmed	CDK6 inhibits white to beige fat transition by suppressing RUNX1
title_sort	cdk6 inhibits white to beige fat transition by suppressing runx1
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Beige adipocytes can arise from transdifferentiation of mature white adipocytes. Here the authors identify CDK6 as a key molecule involved in the white-to-beige adipocyte transdifferentiation and, therefore, as a regulator of organismal energy homeostasis in mice.
url	https://doi.org/10.1038/s41467-018-03451-1
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CDK6 inhibits white to beige fat transition by suppressing RUNX1

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