Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy

Abstract Background and objectives The survival rate of patients with advanced oesophageal cancer is very low and can vary significantly, even among patients with the same TNM stage. It is important to look for indicators that are economical and readily available to predict overall survival. The aim...

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Main Authors: Ke-Jie Li, Xiao-Fang Xia, Meng Su, Hui Zhang, Wen-Hao Chen, Chang-Lin Zou
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Cancer
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12885-019-6157-4
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spelling doaj-1755c7eaa4bf45c4955d97221f0ac4522020-11-25T03:34:42ZengBMCBMC Cancer1471-24072019-10-011911910.1186/s12885-019-6157-4Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapyKe-Jie Li0Xiao-Fang Xia1Meng Su2Hui Zhang3Wen-Hao Chen4Chang-Lin Zou5Wenzhou Medical UniversityWenzhou Medical UniversityDepartment of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou Medical UniversityWenzhou Medical UniversityDepartment of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background and objectives The survival rate of patients with advanced oesophageal cancer is very low and can vary significantly, even among patients with the same TNM stage. It is important to look for indicators that are economical and readily available to predict overall survival. The aim of this study was to determine whether lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) could be potential predictors of survival in patients with advanced oesophageal squamous cell carcinoma (ESCC) undergoing concurrent chemoradiotherapy. Methods Differences in survival among 204 patients with advanced oesophageal cancer who underwent concurrent chemoradiotherapy were collected and analysed. Univariate and multivariate COX regression analyses were used to investigate the association between blood inflammatory markers and patient survival before treatment. Results Univariate COX regression analyses showed that a history of alcohol use, neutrophil count, LMR, NLR, tumour length, and N stage were significantly associated with the survival of tumour patients receiving concurrent chemoradiotherapy. Multivariate COX regression analysis showed that NLR and LMR were predictors of outcome in tumour patients receiving chemoradiotherapy. According to receiver operating characteristic (ROC) curve analysis, the AUC of LMR and NLR was 0.734 and 0.749, and the best cutoff point for LMR and NLR was 3.03 and 2.64, respectively. Conclusions LMR and NLR can be used to predict the survival of patients with advanced oesophageal cancer receiving concurrent chemoradiotherapy, thereby providing clinicians with suggestions for further treatment options.http://link.springer.com/article/10.1186/s12885-019-6157-4Oesophageal cancerBlood inflammatory markersConcurrent chemoradiotherapyOverall survival
collection DOAJ
language English
format Article
sources DOAJ
author Ke-Jie Li
Xiao-Fang Xia
Meng Su
Hui Zhang
Wen-Hao Chen
Chang-Lin Zou
spellingShingle Ke-Jie Li
Xiao-Fang Xia
Meng Su
Hui Zhang
Wen-Hao Chen
Chang-Lin Zou
Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy
BMC Cancer
Oesophageal cancer
Blood inflammatory markers
Concurrent chemoradiotherapy
Overall survival
author_facet Ke-Jie Li
Xiao-Fang Xia
Meng Su
Hui Zhang
Wen-Hao Chen
Chang-Lin Zou
author_sort Ke-Jie Li
title Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy
title_short Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy
title_full Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy
title_fullStr Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy
title_full_unstemmed Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy
title_sort predictive value of lymphocyte-to-monocyte ratio (lmr) and neutrophil-to-lymphocyte ratio (nlr) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy
publisher BMC
series BMC Cancer
issn 1471-2407
publishDate 2019-10-01
description Abstract Background and objectives The survival rate of patients with advanced oesophageal cancer is very low and can vary significantly, even among patients with the same TNM stage. It is important to look for indicators that are economical and readily available to predict overall survival. The aim of this study was to determine whether lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) could be potential predictors of survival in patients with advanced oesophageal squamous cell carcinoma (ESCC) undergoing concurrent chemoradiotherapy. Methods Differences in survival among 204 patients with advanced oesophageal cancer who underwent concurrent chemoradiotherapy were collected and analysed. Univariate and multivariate COX regression analyses were used to investigate the association between blood inflammatory markers and patient survival before treatment. Results Univariate COX regression analyses showed that a history of alcohol use, neutrophil count, LMR, NLR, tumour length, and N stage were significantly associated with the survival of tumour patients receiving concurrent chemoradiotherapy. Multivariate COX regression analysis showed that NLR and LMR were predictors of outcome in tumour patients receiving chemoradiotherapy. According to receiver operating characteristic (ROC) curve analysis, the AUC of LMR and NLR was 0.734 and 0.749, and the best cutoff point for LMR and NLR was 3.03 and 2.64, respectively. Conclusions LMR and NLR can be used to predict the survival of patients with advanced oesophageal cancer receiving concurrent chemoradiotherapy, thereby providing clinicians with suggestions for further treatment options.
topic Oesophageal cancer
Blood inflammatory markers
Concurrent chemoradiotherapy
Overall survival
url http://link.springer.com/article/10.1186/s12885-019-6157-4
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