Effects of sertraline and fluoxetine on p-glycoprotein at barrier sites: in vivo and in vitro approaches.
Retention of substances from systemic circulation in the brain and testes are limited due to high levels of P-glycoprotein (P-gp) in the luminal membranes of brain and testes capillary endothelial cells. From a clinical perspective, P-gp rapidly extrudes lipophilic therapeutic agents, which then fai...
Main Authors: | Amita Kapoor, Majid Iqbal, Sophie Petropoulos, Hay Lam Ho, William Gibb, Stephen G Matthews |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3585317?pdf=render |
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