Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease
Background/Aims Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical out...
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doaj-1761712c62cd4825b9e5c7a3b17b9c612021-08-10T01:10:39ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482019-07-0134485886610.3904/kjim.2017.058169967Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney diseaseSeon Ha Baek0Ran-hui Cha1Shin Wook Kang2Cheol Whee Park3Dae Ryong Cha4Sung Gyun Kim5Sun Ae Yoon6Sejoong Kim7Sang-Youb Han8Jung Hwan Park9Jae Hyun Chang10Chun Soo Lim11Yon Su Kim12Ki Young Na13 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea Department of Internal Medicine, National Medical Center, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea Department of Internal Medicine, College of Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea, Uijeongbu, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaBackground/Aims Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical outcomes in patients with CKD. We aimed to determine whether the level of circulating renalase was associated with CKD progression, MACCEs, and all-cause mortality, using data from a prospective randomized controlled study, Kremezin STudy Against Renal disease progression in Korea (K-STAR; NCT 00860431). Methods A retrospective analysis of the K-STAR data was performed including 383 patients with CKD (mean age, 56.4 years; male/female, 252/131). We measured circulating renalase levels and examined the effects of these levels on clinical outcomes. Results The mean level of serum renalase was 75.8 ± 34.8 μg/mL. In the multivariable analysis, lower hemoglobin levels, higher serum creatinine levels, and diabetes mellitus were significantly associated with a higher renalase levels. Over the course of a mean follow-up period of 56 months, 25 deaths and 61 MACCEs occurred. Among 322 patients in whom these outcomes were assessed, 137 adverse renal outcomes occurred after a mean follow-up period of 27.8 months. Each 10-μg/mL increase in serum renalase was associated with significantly greater hazards of all-cause mortality and adverse renal outcomes (hazard ratio [HR] = 1.112, p = 0.049; HR = 1.052, p = 0.045). However, serum renalase level was not associated with the rate of MACCEs in patients with CKD. Conclusions Our results indicated that circulating renalase might be a predictor of mortality and adverse renal outcomes in patients with CKD.http://www.kjim.org/upload/pdf/kjim-2017-058.pdfchronic kidney diseaserenalasemortalityend-stage renal disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seon Ha Baek Ran-hui Cha Shin Wook Kang Cheol Whee Park Dae Ryong Cha Sung Gyun Kim Sun Ae Yoon Sejoong Kim Sang-Youb Han Jung Hwan Park Jae Hyun Chang Chun Soo Lim Yon Su Kim Ki Young Na |
spellingShingle |
Seon Ha Baek Ran-hui Cha Shin Wook Kang Cheol Whee Park Dae Ryong Cha Sung Gyun Kim Sun Ae Yoon Sejoong Kim Sang-Youb Han Jung Hwan Park Jae Hyun Chang Chun Soo Lim Yon Su Kim Ki Young Na Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease The Korean Journal of Internal Medicine chronic kidney disease renalase mortality end-stage renal disease |
author_facet |
Seon Ha Baek Ran-hui Cha Shin Wook Kang Cheol Whee Park Dae Ryong Cha Sung Gyun Kim Sun Ae Yoon Sejoong Kim Sang-Youb Han Jung Hwan Park Jae Hyun Chang Chun Soo Lim Yon Su Kim Ki Young Na |
author_sort |
Seon Ha Baek |
title |
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease |
title_short |
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease |
title_full |
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease |
title_fullStr |
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease |
title_full_unstemmed |
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease |
title_sort |
circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease |
publisher |
The Korean Association of Internal Medicine |
series |
The Korean Journal of Internal Medicine |
issn |
1226-3303 2005-6648 |
publishDate |
2019-07-01 |
description |
Background/Aims Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical outcomes in patients with CKD. We aimed to determine whether the level of circulating renalase was associated with CKD progression, MACCEs, and all-cause mortality, using data from a prospective randomized controlled study, Kremezin STudy Against Renal disease progression in Korea (K-STAR; NCT 00860431). Methods A retrospective analysis of the K-STAR data was performed including 383 patients with CKD (mean age, 56.4 years; male/female, 252/131). We measured circulating renalase levels and examined the effects of these levels on clinical outcomes. Results The mean level of serum renalase was 75.8 ± 34.8 μg/mL. In the multivariable analysis, lower hemoglobin levels, higher serum creatinine levels, and diabetes mellitus were significantly associated with a higher renalase levels. Over the course of a mean follow-up period of 56 months, 25 deaths and 61 MACCEs occurred. Among 322 patients in whom these outcomes were assessed, 137 adverse renal outcomes occurred after a mean follow-up period of 27.8 months. Each 10-μg/mL increase in serum renalase was associated with significantly greater hazards of all-cause mortality and adverse renal outcomes (hazard ratio [HR] = 1.112, p = 0.049; HR = 1.052, p = 0.045). However, serum renalase level was not associated with the rate of MACCEs in patients with CKD. Conclusions Our results indicated that circulating renalase might be a predictor of mortality and adverse renal outcomes in patients with CKD. |
topic |
chronic kidney disease renalase mortality end-stage renal disease |
url |
http://www.kjim.org/upload/pdf/kjim-2017-058.pdf |
work_keys_str_mv |
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