Simple Elastic Network Models for Exhaustive Analysis of Long Double-Stranded DNA Dynamics with Sequence Geometry Dependence.
Simple elastic network models of DNA were developed to reveal the structure-dynamics relationships for several nucleotide sequences. First, we propose a simple all-atom elastic network model of DNA that can explain the profiles of temperature factors for several crystal structures of DNA. Second, we...
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2015-01-01
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Online Access: | https://doi.org/10.1371/journal.pone.0143760 |
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doaj-176c2fa688b141d3b6f3b488e2c7e3c32021-03-03T19:57:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014376010.1371/journal.pone.0143760Simple Elastic Network Models for Exhaustive Analysis of Long Double-Stranded DNA Dynamics with Sequence Geometry Dependence.Shuhei IsamiNaoaki SakamotoHiraku NishimoriAkinori AwazuSimple elastic network models of DNA were developed to reveal the structure-dynamics relationships for several nucleotide sequences. First, we propose a simple all-atom elastic network model of DNA that can explain the profiles of temperature factors for several crystal structures of DNA. Second, we propose a coarse-grained elastic network model of DNA, where each nucleotide is described only by one node. This model could effectively reproduce the detailed dynamics obtained with the all-atom elastic network model according to the sequence-dependent geometry. Through normal-mode analysis for the coarse-grained elastic network model, we exhaustively analyzed the dynamic features of a large number of long DNA sequences, approximately ∼150 bp in length. These analyses revealed positive correlations between the nucleosome-forming abilities and the inter-strand fluctuation strength of double-stranded DNA for several DNA sequences.https://doi.org/10.1371/journal.pone.0143760 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuhei Isami Naoaki Sakamoto Hiraku Nishimori Akinori Awazu |
spellingShingle |
Shuhei Isami Naoaki Sakamoto Hiraku Nishimori Akinori Awazu Simple Elastic Network Models for Exhaustive Analysis of Long Double-Stranded DNA Dynamics with Sequence Geometry Dependence. PLoS ONE |
author_facet |
Shuhei Isami Naoaki Sakamoto Hiraku Nishimori Akinori Awazu |
author_sort |
Shuhei Isami |
title |
Simple Elastic Network Models for Exhaustive Analysis of Long Double-Stranded DNA Dynamics with Sequence Geometry Dependence. |
title_short |
Simple Elastic Network Models for Exhaustive Analysis of Long Double-Stranded DNA Dynamics with Sequence Geometry Dependence. |
title_full |
Simple Elastic Network Models for Exhaustive Analysis of Long Double-Stranded DNA Dynamics with Sequence Geometry Dependence. |
title_fullStr |
Simple Elastic Network Models for Exhaustive Analysis of Long Double-Stranded DNA Dynamics with Sequence Geometry Dependence. |
title_full_unstemmed |
Simple Elastic Network Models for Exhaustive Analysis of Long Double-Stranded DNA Dynamics with Sequence Geometry Dependence. |
title_sort |
simple elastic network models for exhaustive analysis of long double-stranded dna dynamics with sequence geometry dependence. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Simple elastic network models of DNA were developed to reveal the structure-dynamics relationships for several nucleotide sequences. First, we propose a simple all-atom elastic network model of DNA that can explain the profiles of temperature factors for several crystal structures of DNA. Second, we propose a coarse-grained elastic network model of DNA, where each nucleotide is described only by one node. This model could effectively reproduce the detailed dynamics obtained with the all-atom elastic network model according to the sequence-dependent geometry. Through normal-mode analysis for the coarse-grained elastic network model, we exhaustively analyzed the dynamic features of a large number of long DNA sequences, approximately ∼150 bp in length. These analyses revealed positive correlations between the nucleosome-forming abilities and the inter-strand fluctuation strength of double-stranded DNA for several DNA sequences. |
url |
https://doi.org/10.1371/journal.pone.0143760 |
work_keys_str_mv |
AT shuheiisami simpleelasticnetworkmodelsforexhaustiveanalysisoflongdoublestrandeddnadynamicswithsequencegeometrydependence AT naoakisakamoto simpleelasticnetworkmodelsforexhaustiveanalysisoflongdoublestrandeddnadynamicswithsequencegeometrydependence AT hirakunishimori simpleelasticnetworkmodelsforexhaustiveanalysisoflongdoublestrandeddnadynamicswithsequencegeometrydependence AT akinoriawazu simpleelasticnetworkmodelsforexhaustiveanalysisoflongdoublestrandeddnadynamicswithsequencegeometrydependence |
_version_ |
1714824772836130816 |