Human cellular restriction factors that target HIV-1 replication

Human cellular restriction factors that target HIV-1 replication

<p>Abstract</p> <p>Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (...

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Bibliographic Details
Main Authors: Jeang Kuan-Teh, Luban Jeremy, Strebel Klaus
Format: Article
Language:English
Published: BMC 2009-09-01
Series:BMC Medicine
Online Access:http://www.biomedcentral.com/1741-7015/7/48
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spelling doaj-1777c7e97d2443a49e3a690cf1623a202020-11-24T23:28:06ZengBMCBMC Medicine1741-70152009-09-01714810.1186/1741-7015-7-48Human cellular restriction factors that target HIV-1 replicationJeang Kuan-TehLuban JeremyStrebel Klaus<p>Abstract</p> <p>Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.</p> http://www.biomedcentral.com/1741-7015/7/48
collection DOAJ
language English
format Article
sources DOAJ
author Jeang Kuan-Teh
Luban Jeremy
Strebel Klaus
spellingShingle Jeang Kuan-Teh
Luban Jeremy
Strebel Klaus
Human cellular restriction factors that target HIV-1 replication
BMC Medicine
author_facet Jeang Kuan-Teh
Luban Jeremy
Strebel Klaus
author_sort Jeang Kuan-Teh
title Human cellular restriction factors that target HIV-1 replication
title_short Human cellular restriction factors that target HIV-1 replication
title_full Human cellular restriction factors that target HIV-1 replication
title_fullStr Human cellular restriction factors that target HIV-1 replication
title_full_unstemmed Human cellular restriction factors that target HIV-1 replication
title_sort human cellular restriction factors that target hiv-1 replication
publisher BMC
series BMC Medicine
issn 1741-7015
publishDate 2009-09-01
description <p>Abstract</p> <p>Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.</p>
url http://www.biomedcentral.com/1741-7015/7/48
work_keys_str_mv AT jeangkuanteh humancellularrestrictionfactorsthattargethiv1replication
AT lubanjeremy humancellularrestrictionfactorsthattargethiv1replication
AT strebelklaus humancellularrestrictionfactorsthattargethiv1replication
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