Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface

The blood circulation time is important to the biomedical application of nanomaterials. Here, the authors explore the effect of protein corona formation on the blood residency of nanomaterials and show circulation times are governed by the dynamic remodelling of protein opsonins in vivo.

Bibliographic Details
Main Authors:	Srinivas Abbina, Lily E. Takeuchi, Parambath Anilkumar, Kai Yu, Jason C. Rogalski, Rajesh A. Shenoi, Iren Constantinescu, Jayachandran N. Kizhakkedathu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16772-x

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spelling	doaj-1781b338e91c42bfbfee966be2fca34b2021-06-20T11:13:50ZengNature Publishing GroupNature Communications2041-17232020-06-0111111210.1038/s41467-020-16772-xBlood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerfaceSrinivas Abbina0Lily E. Takeuchi1Parambath Anilkumar2Kai Yu3Jason C. Rogalski4Rajesh A. Shenoi5Iren Constantinescu6Jayachandran N. Kizhakkedathu7Centre for Blood Research, Life Sciences Institute, The University of British ColumbiaCentre for Blood Research, Life Sciences Institute, The University of British ColumbiaCentre for Blood Research, Life Sciences Institute, The University of British ColumbiaCentre for Blood Research, Life Sciences Institute, The University of British ColumbiaCentre for High Throughput Biology, Michael Smith Laboratories, The University of British ColumbiaInter University Centre for Biomedical Research & Super Speciality Hospital, Mahatma Gandhi University Campus at ThalappadyCentre for Blood Research, Life Sciences Institute, The University of British ColumbiaCentre for Blood Research, Life Sciences Institute, The University of British ColumbiaThe blood circulation time is important to the biomedical application of nanomaterials. Here, the authors explore the effect of protein corona formation on the blood residency of nanomaterials and show circulation times are governed by the dynamic remodelling of protein opsonins in vivo.https://doi.org/10.1038/s41467-020-16772-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Srinivas Abbina Lily E. Takeuchi Parambath Anilkumar Kai Yu Jason C. Rogalski Rajesh A. Shenoi Iren Constantinescu Jayachandran N. Kizhakkedathu
spellingShingle	Srinivas Abbina Lily E. Takeuchi Parambath Anilkumar Kai Yu Jason C. Rogalski Rajesh A. Shenoi Iren Constantinescu Jayachandran N. Kizhakkedathu Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface Nature Communications
author_facet	Srinivas Abbina Lily E. Takeuchi Parambath Anilkumar Kai Yu Jason C. Rogalski Rajesh A. Shenoi Iren Constantinescu Jayachandran N. Kizhakkedathu
author_sort	Srinivas Abbina
title	Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface
title_short	Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface
title_full	Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface
title_fullStr	Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface
title_full_unstemmed	Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface
title_sort	blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	The blood circulation time is important to the biomedical application of nanomaterials. Here, the authors explore the effect of protein corona formation on the blood residency of nanomaterials and show circulation times are governed by the dynamic remodelling of protein opsonins in vivo.
url	https://doi.org/10.1038/s41467-020-16772-x
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Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface

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