Recent advances in understanding psoriasis [version 1; referees: 2 approved]
T helper (Th) cells producing interleukin (IL)-17, IL-22, and tumor necrosis factor (TNF) form the key T cell population driving psoriasis pathogenesis. They orchestrate the inflammation in the skin that results in the proliferation of keratinocytes and endothelial cells. Besides Th17 cells, other i...
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doaj-1784fc61e2074b0a84cff757627ce8252020-11-25T03:43:49ZengF1000 Research LtdF1000Research2046-14022016-04-01510.12688/f1000research.7927.18534Recent advances in understanding psoriasis [version 1; referees: 2 approved]Franziska C. Eberle0Jürgen Brück1Julia Holstein2Kiyoshi Hirahara3Kamran Ghoreschi4Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, GermanyDepartment of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, GermanyDepartment of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, GermanyDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, GermanyT helper (Th) cells producing interleukin (IL)-17, IL-22, and tumor necrosis factor (TNF) form the key T cell population driving psoriasis pathogenesis. They orchestrate the inflammation in the skin that results in the proliferation of keratinocytes and endothelial cells. Besides Th17 cells, other immune cells that are capable of producing IL-17-associated cytokines participate in psoriatic inflammation. Recent advances in psoriasis research improved our understanding of the cellular and molecular players that are involved in Th17 pathology and inflammatory pathways in the skin. The inflammation-driving actions of TNF in psoriasis are already well known and antibodies against TNF are successful in the treatment of Th17-mediated psoriatic skin inflammation. A further key cytokine with potent IL-17-/IL-22-promoting properties is IL-23. Therapeutics directly neutralizing IL-23 or IL-17 itself are now extending the therapeutic spectrum of antipsoriatic agents and further developments are on the way. The enormous progress in psoriasis research allows us to control this Th17-mediated inflammatory skin disease in many patients.http://f1000research.com/articles/5-770/v1Atopic Dermatitis & Other Forms of EczemaAutoimmunityDermatologic PharmacologyImmunopharmacology & Hematologic PharmacologyInnate ImmunityLeukocyte Signaling & Gene ExpressionMedical GeneticsPhotodermatology & Skin AgingPsoriasis & Other Inflammatory Diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Franziska C. Eberle Jürgen Brück Julia Holstein Kiyoshi Hirahara Kamran Ghoreschi |
spellingShingle |
Franziska C. Eberle Jürgen Brück Julia Holstein Kiyoshi Hirahara Kamran Ghoreschi Recent advances in understanding psoriasis [version 1; referees: 2 approved] F1000Research Atopic Dermatitis & Other Forms of Eczema Autoimmunity Dermatologic Pharmacology Immunopharmacology & Hematologic Pharmacology Innate Immunity Leukocyte Signaling & Gene Expression Medical Genetics Photodermatology & Skin Aging Psoriasis & Other Inflammatory Diseases |
author_facet |
Franziska C. Eberle Jürgen Brück Julia Holstein Kiyoshi Hirahara Kamran Ghoreschi |
author_sort |
Franziska C. Eberle |
title |
Recent advances in understanding psoriasis [version 1; referees: 2 approved] |
title_short |
Recent advances in understanding psoriasis [version 1; referees: 2 approved] |
title_full |
Recent advances in understanding psoriasis [version 1; referees: 2 approved] |
title_fullStr |
Recent advances in understanding psoriasis [version 1; referees: 2 approved] |
title_full_unstemmed |
Recent advances in understanding psoriasis [version 1; referees: 2 approved] |
title_sort |
recent advances in understanding psoriasis [version 1; referees: 2 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2016-04-01 |
description |
T helper (Th) cells producing interleukin (IL)-17, IL-22, and tumor necrosis factor (TNF) form the key T cell population driving psoriasis pathogenesis. They orchestrate the inflammation in the skin that results in the proliferation of keratinocytes and endothelial cells. Besides Th17 cells, other immune cells that are capable of producing IL-17-associated cytokines participate in psoriatic inflammation. Recent advances in psoriasis research improved our understanding of the cellular and molecular players that are involved in Th17 pathology and inflammatory pathways in the skin. The inflammation-driving actions of TNF in psoriasis are already well known and antibodies against TNF are successful in the treatment of Th17-mediated psoriatic skin inflammation. A further key cytokine with potent IL-17-/IL-22-promoting properties is IL-23. Therapeutics directly neutralizing IL-23 or IL-17 itself are now extending the therapeutic spectrum of antipsoriatic agents and further developments are on the way. The enormous progress in psoriasis research allows us to control this Th17-mediated inflammatory skin disease in many patients. |
topic |
Atopic Dermatitis & Other Forms of Eczema Autoimmunity Dermatologic Pharmacology Immunopharmacology & Hematologic Pharmacology Innate Immunity Leukocyte Signaling & Gene Expression Medical Genetics Photodermatology & Skin Aging Psoriasis & Other Inflammatory Diseases |
url |
http://f1000research.com/articles/5-770/v1 |
work_keys_str_mv |
AT franziskaceberle recentadvancesinunderstandingpsoriasisversion1referees2approved AT jurgenbruck recentadvancesinunderstandingpsoriasisversion1referees2approved AT juliaholstein recentadvancesinunderstandingpsoriasisversion1referees2approved AT kiyoshihirahara recentadvancesinunderstandingpsoriasisversion1referees2approved AT kamranghoreschi recentadvancesinunderstandingpsoriasisversion1referees2approved |
_version_ |
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