Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome
Twenty eight 7-substitued fangchinoline analogues, of which twenty two were novel, were synthesized and evaluated for their effect to inhibit lipopolysaccharide/nigericin (LPS/NIG)-induced IL-1β release at both cell and protein levels at the concentration of 5 μM. Among them, compo...
Main Authors: | Ting Liu, Qingxuan Zeng, Xiaoqiang Zhao, Wei Wei, Yinghong Li, Hongbin Deng, Danqing Song |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-03-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/24/6/1154 |
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