Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles

Mutations in many centriolar protein-encoding genes cause primary microcephaly. Here the authors show that human microcephaly protein RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles

Bibliographic Details
Main Authors: Hsin-Yi Chen, Chien-Ting Wu, Chieh-Ju C. Tang, Yi-Nan Lin, Won-Jing Wang, Tang K. Tang
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00305-0
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spelling doaj-17908d7c695d4446b67c1c19166df7322021-01-31T12:48:59ZengNature Publishing GroupNature Communications2041-17232017-08-018111410.1038/s41467-017-00305-0Human microcephaly protein RTTN interacts with STIL and is required to build full-length centriolesHsin-Yi Chen0Chien-Ting Wu1Chieh-Ju C. Tang2Yi-Nan Lin3Won-Jing Wang4Tang K. Tang5Graduate Institution of Life Sciences, National Defense Medical CenterInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang-Ming UniversityGraduate Institution of Life Sciences, National Defense Medical CenterMutations in many centriolar protein-encoding genes cause primary microcephaly. Here the authors show that human microcephaly protein RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioleshttps://doi.org/10.1038/s41467-017-00305-0
collection DOAJ
language English
format Article
sources DOAJ
author Hsin-Yi Chen
Chien-Ting Wu
Chieh-Ju C. Tang
Yi-Nan Lin
Won-Jing Wang
Tang K. Tang
spellingShingle Hsin-Yi Chen
Chien-Ting Wu
Chieh-Ju C. Tang
Yi-Nan Lin
Won-Jing Wang
Tang K. Tang
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
Nature Communications
author_facet Hsin-Yi Chen
Chien-Ting Wu
Chieh-Ju C. Tang
Yi-Nan Lin
Won-Jing Wang
Tang K. Tang
author_sort Hsin-Yi Chen
title Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
title_short Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
title_full Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
title_fullStr Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
title_full_unstemmed Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles
title_sort human microcephaly protein rttn interacts with stil and is required to build full-length centrioles
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-08-01
description Mutations in many centriolar protein-encoding genes cause primary microcephaly. Here the authors show that human microcephaly protein RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles
url https://doi.org/10.1038/s41467-017-00305-0
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AT yinanlin humanmicrocephalyproteinrttninteractswithstilandisrequiredtobuildfulllengthcentrioles
AT wonjingwang humanmicrocephalyproteinrttninteractswithstilandisrequiredtobuildfulllengthcentrioles
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