Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor.
Adaptation is a common feature of many sensory systems. But its occurrence to pain sensation has remained elusive. Here we address the problem at the receptor level and show that the capsaicin ion channel TRPV1, which mediates nociception at the peripheral nerve terminals, possesses properties essen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-02-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC3279049?pdf=render |