Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy

Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy

MicroRNAs represent nonprotein coding small RNA molecules that are very stable to degradation and responsible for gene silencing in most eukaryotic cells. Increased evidence has been accumulating over the years about their potential value as biomarkers for several diseases. MicroRNAs were predicted...

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Main Authors: Dragos Cretoiu, Jiahong Xu, Junjie Xiao, Nicolae Suciu, Sanda Maria Cretoiu
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2016/3851054
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spelling doaj-179857022c074d63bd4c7f313cf5434e2020-11-25T01:06:25ZengHindawi LimitedDisease Markers0278-02401875-86302016-01-01201610.1155/2016/38510543851054Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of PregnancyDragos Cretoiu0Jiahong Xu1Junjie Xiao2Nicolae Suciu3Sanda Maria Cretoiu4Division of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, ChinaRegeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai 200444, ChinaDepartment of Obstetrics and Gynecology, Polizu Clinical Hospital, Carol Davila University of Medicine and Pharmacy, 011062 Bucharest, RomaniaDivision of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaMicroRNAs represent nonprotein coding small RNA molecules that are very stable to degradation and responsible for gene silencing in most eukaryotic cells. Increased evidence has been accumulating over the years about their potential value as biomarkers for several diseases. MicroRNAs were predicted to be involved in nearly all biological processes from development to oncogenesis. In this review, we address the importance of circulating microRNAs in different conditions associated with pregnancy starting with the implantation period to preeclampsia and we shortly describe the correlation between placental circulating miRNAs and pregnancy status. We also discuss the importance of microRNAs in recurrent abortion and ectopic pregnancy.http://dx.doi.org/10.1155/2016/3851054
collection DOAJ
language English
format Article
sources DOAJ
author Dragos Cretoiu
Jiahong Xu
Junjie Xiao
Nicolae Suciu
Sanda Maria Cretoiu
spellingShingle Dragos Cretoiu
Jiahong Xu
Junjie Xiao
Nicolae Suciu
Sanda Maria Cretoiu
Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy
Disease Markers
author_facet Dragos Cretoiu
Jiahong Xu
Junjie Xiao
Nicolae Suciu
Sanda Maria Cretoiu
author_sort Dragos Cretoiu
title Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy
title_short Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy
title_full Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy
title_fullStr Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy
title_full_unstemmed Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy
title_sort circulating micrornas as potential molecular biomarkers in pathophysiological evolution of pregnancy
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2016-01-01
description MicroRNAs represent nonprotein coding small RNA molecules that are very stable to degradation and responsible for gene silencing in most eukaryotic cells. Increased evidence has been accumulating over the years about their potential value as biomarkers for several diseases. MicroRNAs were predicted to be involved in nearly all biological processes from development to oncogenesis. In this review, we address the importance of circulating microRNAs in different conditions associated with pregnancy starting with the implantation period to preeclampsia and we shortly describe the correlation between placental circulating miRNAs and pregnancy status. We also discuss the importance of microRNAs in recurrent abortion and ectopic pregnancy.
url http://dx.doi.org/10.1155/2016/3851054
work_keys_str_mv AT dragoscretoiu circulatingmicrornasaspotentialmolecularbiomarkersinpathophysiologicalevolutionofpregnancy
AT jiahongxu circulatingmicrornasaspotentialmolecularbiomarkersinpathophysiologicalevolutionofpregnancy
AT junjiexiao circulatingmicrornasaspotentialmolecularbiomarkersinpathophysiologicalevolutionofpregnancy
AT nicolaesuciu circulatingmicrornasaspotentialmolecularbiomarkersinpathophysiologicalevolutionofpregnancy
AT sandamariacretoiu circulatingmicrornasaspotentialmolecularbiomarkersinpathophysiologicalevolutionofpregnancy
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