Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking
Background: In Parkinson’s disease (PD), the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST) conditions. However, multitasking situations are considered more daily relevant.Methods: Thirty-nine early to moderate PD patients perfor...
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doaj-17a2cd6a72eb483fac6ba7ed3f02e4222020-11-25T01:06:47ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-01-01810.3389/fnagi.2016.00004163117Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual taskingMorad eElshehabi0Katrin S Maier1Sandra E Hasmann2Susanne eNussbaum3Heinz eHerbst4Tanja eHeger5Daniela eBerg6Markus A Hobert7Walter eMaetzler8Hertie Institute for Clinical and Brain Research, Department of Neurodegeneration, Center for Neurology, University of Tuebingen and German Center for Neurodegenerative Disease (DZNE)Hertie Institute for Clinical and Brain Research, Department of Neurodegeneration, Center for Neurology, University of Tuebingen and German Center for Neurodegenerative Disease (DZNE)Hertie Institute for Clinical and Brain Research, Department of Neurodegeneration, Center for Neurology, University of Tuebingen and German Center for Neurodegenerative Disease (DZNE)Hertie Institute for Clinical and Brain Research, Department of Neurodegeneration, Center for Neurology, University of Tuebingen and German Center for Neurodegenerative Disease (DZNE)Private Neurology PracticeHertie Institute for Clinical and Brain Research, Department of Neurodegeneration, Center for Neurology, University of Tuebingen and German Center for Neurodegenerative Disease (DZNE)Hertie Institute for Clinical and Brain Research, Department of Neurodegeneration, Center for Neurology, University of Tuebingen and German Center for Neurodegenerative Disease (DZNE)Hertie Institute for Clinical and Brain Research, Department of Neurodegeneration, Center for Neurology, University of Tuebingen and German Center for Neurodegenerative Disease (DZNE)Hertie Institute for Clinical and Brain Research, Department of Neurodegeneration, Center for Neurology, University of Tuebingen and German Center for Neurodegenerative Disease (DZNE)Background: In Parkinson’s disease (PD), the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST) conditions. However, multitasking situations are considered more daily relevant.Methods: Thirty-nine early to moderate PD patients performed the following standarized ST and dual tasks (DT) as fast as possible for one minute during On- and Off-medication while wearing inertial sensors: straight walking and turning, checking boxes, and subtracting serial 7s. Quantitative gait parameters, as well as velocity of the secondary tasks were analyzed.Results: The following parameters improved significantly in On-medication during ST: gait velocity during straight walking (p=0.03); step duration (p=0.048) and peak velocity (p=0.04) during turning; velocity of checking boxes during ST (p=0.04) and DT (p=0.04). Velocity of checking boxes was the only parameter that also improved during DT.Conclusion: These results suggest that dopaminergic medication does not relevantly influence straight walking and turning in early to moderate PD during DT.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00004/fullGaitParkinson’s diseaseDual taskingwearable sensorsturning |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Morad eElshehabi Katrin S Maier Sandra E Hasmann Susanne eNussbaum Heinz eHerbst Tanja eHeger Daniela eBerg Markus A Hobert Walter eMaetzler |
spellingShingle |
Morad eElshehabi Katrin S Maier Sandra E Hasmann Susanne eNussbaum Heinz eHerbst Tanja eHeger Daniela eBerg Markus A Hobert Walter eMaetzler Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking Frontiers in Aging Neuroscience Gait Parkinson’s disease Dual tasking wearable sensors turning |
author_facet |
Morad eElshehabi Katrin S Maier Sandra E Hasmann Susanne eNussbaum Heinz eHerbst Tanja eHeger Daniela eBerg Markus A Hobert Walter eMaetzler |
author_sort |
Morad eElshehabi |
title |
Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking |
title_short |
Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking |
title_full |
Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking |
title_fullStr |
Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking |
title_full_unstemmed |
Limited effect of dopaminergic medication on straight walking and turning in early to moderate Parkinson’s disease during single and dual tasking |
title_sort |
limited effect of dopaminergic medication on straight walking and turning in early to moderate parkinson’s disease during single and dual tasking |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2016-01-01 |
description |
Background: In Parkinson’s disease (PD), the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST) conditions. However, multitasking situations are considered more daily relevant.Methods: Thirty-nine early to moderate PD patients performed the following standarized ST and dual tasks (DT) as fast as possible for one minute during On- and Off-medication while wearing inertial sensors: straight walking and turning, checking boxes, and subtracting serial 7s. Quantitative gait parameters, as well as velocity of the secondary tasks were analyzed.Results: The following parameters improved significantly in On-medication during ST: gait velocity during straight walking (p=0.03); step duration (p=0.048) and peak velocity (p=0.04) during turning; velocity of checking boxes during ST (p=0.04) and DT (p=0.04). Velocity of checking boxes was the only parameter that also improved during DT.Conclusion: These results suggest that dopaminergic medication does not relevantly influence straight walking and turning in early to moderate PD during DT. |
topic |
Gait Parkinson’s disease Dual tasking wearable sensors turning |
url |
http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00004/full |
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