The association between a fracture risk tool and frailty: Geelong Osteoporosis Study
Abstract Background Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailty overlap with risk factors for fragility fractures. The aim of this study was to investigate the association between the fracture risk assessment tool (FRAX®) an...
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doaj-17a7081dfa7b42c7a32f2c7e5a3926102020-11-25T03:54:59ZengBMCBMC Geriatrics1471-23182020-06-012011910.1186/s12877-020-01595-8The association between a fracture risk tool and frailty: Geelong Osteoporosis StudyMonica C. Tembo0Kara L. Holloway-Kew1Mohammadreza Mohebbi2Sophia X. Sui3Sarah M. Hosking4Sharon L. Brennan-Olsen5Lana J. Williams6Mark A. Kotowicz7Julie A. Pasco8Epi-Centre for Healthy Ageing, Deakin UniversityEpi-Centre for Healthy Ageing, Deakin UniversityFaculty of Health, Biostatistics Unit, Deakin UniversityEpi-Centre for Healthy Ageing, Deakin UniversityEpi-Centre for Healthy Ageing, Deakin UniversityAustralian Institute for Musculoskeletal Science (AIMSS), The University of MelbourneEpi-Centre for Healthy Ageing, Deakin UniversityEpi-Centre for Healthy Ageing, Deakin UniversityEpi-Centre for Healthy Ageing, Deakin UniversityAbstract Background Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailty overlap with risk factors for fragility fractures. The aim of this study was to investigate the association between the fracture risk assessment tool (FRAX®) and frailty. Methods In cross-sectional analysis, frailty status was determined for participants aged 60-90 yr at 15-year follow-up of the Geelong Osteoporosis Study, using a modified Fried frailty phenotype. Using the FRAX on-line tool, scores for hip and major osteoporotic fracture (MOF) were calculated with and without bone mineral density (BMD). Using the area under Receiver Operating Characteristic (AUROC) curves, and FRAX scores calculated at the baseline visit for these participants, we investigated the association of FRAX and frailty 15 years later. Results Forty-seven of 303 women (15.5%) and 41 of 282 men (14.5%) were frail at the 15-year visit. There was a gradient of increasing median FRAX scores from robust to frail. For example, for women, median MOF-FRAX without BMD increased from 5.9 for the robust to 7.5 for the pre-frail and 14.0 for the frail (p < 0.001). In secondary analyses, an association was observed between FRAX and frailty over 15 years, with the highest AUROC for women being 0.72 for MOF-FRAX with BMD, and for men, 0.76 hip-FRAX without BMD. Conclusion An association was observed between FRAX and frailty where frail men and women had higher FRAX-scores compared to the other groups. Preliminary data suggest that FRAX, with or without BMD, may be useful in enhancing the information on frailty. Further research using larger datasets will be required to explore this.http://link.springer.com/article/10.1186/s12877-020-01595-8FrailtyFRAXAssociationOlder adults |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Monica C. Tembo Kara L. Holloway-Kew Mohammadreza Mohebbi Sophia X. Sui Sarah M. Hosking Sharon L. Brennan-Olsen Lana J. Williams Mark A. Kotowicz Julie A. Pasco |
spellingShingle |
Monica C. Tembo Kara L. Holloway-Kew Mohammadreza Mohebbi Sophia X. Sui Sarah M. Hosking Sharon L. Brennan-Olsen Lana J. Williams Mark A. Kotowicz Julie A. Pasco The association between a fracture risk tool and frailty: Geelong Osteoporosis Study BMC Geriatrics Frailty FRAX Association Older adults |
author_facet |
Monica C. Tembo Kara L. Holloway-Kew Mohammadreza Mohebbi Sophia X. Sui Sarah M. Hosking Sharon L. Brennan-Olsen Lana J. Williams Mark A. Kotowicz Julie A. Pasco |
author_sort |
Monica C. Tembo |
title |
The association between a fracture risk tool and frailty: Geelong Osteoporosis Study |
title_short |
The association between a fracture risk tool and frailty: Geelong Osteoporosis Study |
title_full |
The association between a fracture risk tool and frailty: Geelong Osteoporosis Study |
title_fullStr |
The association between a fracture risk tool and frailty: Geelong Osteoporosis Study |
title_full_unstemmed |
The association between a fracture risk tool and frailty: Geelong Osteoporosis Study |
title_sort |
association between a fracture risk tool and frailty: geelong osteoporosis study |
publisher |
BMC |
series |
BMC Geriatrics |
issn |
1471-2318 |
publishDate |
2020-06-01 |
description |
Abstract Background Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailty overlap with risk factors for fragility fractures. The aim of this study was to investigate the association between the fracture risk assessment tool (FRAX®) and frailty. Methods In cross-sectional analysis, frailty status was determined for participants aged 60-90 yr at 15-year follow-up of the Geelong Osteoporosis Study, using a modified Fried frailty phenotype. Using the FRAX on-line tool, scores for hip and major osteoporotic fracture (MOF) were calculated with and without bone mineral density (BMD). Using the area under Receiver Operating Characteristic (AUROC) curves, and FRAX scores calculated at the baseline visit for these participants, we investigated the association of FRAX and frailty 15 years later. Results Forty-seven of 303 women (15.5%) and 41 of 282 men (14.5%) were frail at the 15-year visit. There was a gradient of increasing median FRAX scores from robust to frail. For example, for women, median MOF-FRAX without BMD increased from 5.9 for the robust to 7.5 for the pre-frail and 14.0 for the frail (p < 0.001). In secondary analyses, an association was observed between FRAX and frailty over 15 years, with the highest AUROC for women being 0.72 for MOF-FRAX with BMD, and for men, 0.76 hip-FRAX without BMD. Conclusion An association was observed between FRAX and frailty where frail men and women had higher FRAX-scores compared to the other groups. Preliminary data suggest that FRAX, with or without BMD, may be useful in enhancing the information on frailty. Further research using larger datasets will be required to explore this. |
topic |
Frailty FRAX Association Older adults |
url |
http://link.springer.com/article/10.1186/s12877-020-01595-8 |
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