Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'
Perturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a “monoclonal nose”, glomerular input patterns in the olfactory bulb are massively perturbed and olfactory behaviors are altered. To gain insights into how olfacto...
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doaj-17be6909b1e04e3c94d6140f307a86242021-05-05T00:23:35ZengeLife Sciences Publications LtdeLife2050-084X2016-05-01510.7554/eLife.16335Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'Benjamin Roland0Rebecca Jordan1Dara L Sosulski2Assunta Diodato3Izumi Fukunaga4Ian Wickersham5Kevin M Franks6Andreas T Schaefer7Alexander Fleischmann8https://orcid.org/0000-0001-7956-9096Center for Interdisciplinary Research in Biology, Collège de France, INSERM U1050, CNRS UMR 7241, Paris, FranceThe Francis Crick Institute, London, United Kingdom; Department of Neuroscience, Physiology and Pharmacology, University College London, London, United KingdomWolfson Institute for Biomedical Research, University College London, London, United KingdomCenter for Interdisciplinary Research in Biology, Collège de France, INSERM U1050, CNRS UMR 7241, Paris, FranceThe Francis Crick Institute, London, United Kingdom; Behavioural Neurophysiology, Max-Planck-Institute for Medical Research, Heidelberg, GermanyMIT Genetic Neuroengineering Group, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United StatesDepartment of Neurobiology, Duke University, Durham, United StatesThe Francis Crick Institute, London, United Kingdom; Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom; Behavioural Neurophysiology, Max-Planck-Institute for Medical Research, Heidelberg, Germany; Department of Anatomy and Cell Biology, Faculty of Medicine, University of Heidelberg, Heidelberg, GermanyCenter for Interdisciplinary Research in Biology, Collège de France, INSERM U1050, CNRS UMR 7241, Paris, FrancePerturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a “monoclonal nose”, glomerular input patterns in the olfactory bulb are massively perturbed and olfactory behaviors are altered. To gain insights into how olfactory circuits can process such degraded inputs we characterized odor-evoked responses of olfactory bulb mitral cells and interneurons. Surprisingly, calcium imaging experiments reveal that mitral cell responses in M71 transgenic mice are largely normal, highlighting a remarkable capacity of olfactory circuits to normalize sensory input. In vivo whole cell recordings suggest that feedforward inhibition from olfactory bulb periglomerular cells can mediate this signal normalization. Together, our results identify inhibitory circuits in the olfactory bulb as a mechanistic basis for many of the behavioral phenotypes of mice with a “monoclonal nose” and highlight how substantially degraded odor input can be transformed to yield meaningful olfactory bulb output.https://elifesciences.org/articles/16335olfactionolfactory bulbsignal normalizationexcitation/inhibition balance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benjamin Roland Rebecca Jordan Dara L Sosulski Assunta Diodato Izumi Fukunaga Ian Wickersham Kevin M Franks Andreas T Schaefer Alexander Fleischmann |
spellingShingle |
Benjamin Roland Rebecca Jordan Dara L Sosulski Assunta Diodato Izumi Fukunaga Ian Wickersham Kevin M Franks Andreas T Schaefer Alexander Fleischmann Massive normalization of olfactory bulb output in mice with a 'monoclonal nose' eLife olfaction olfactory bulb signal normalization excitation/inhibition balance |
author_facet |
Benjamin Roland Rebecca Jordan Dara L Sosulski Assunta Diodato Izumi Fukunaga Ian Wickersham Kevin M Franks Andreas T Schaefer Alexander Fleischmann |
author_sort |
Benjamin Roland |
title |
Massive normalization of olfactory bulb output in mice with a 'monoclonal nose' |
title_short |
Massive normalization of olfactory bulb output in mice with a 'monoclonal nose' |
title_full |
Massive normalization of olfactory bulb output in mice with a 'monoclonal nose' |
title_fullStr |
Massive normalization of olfactory bulb output in mice with a 'monoclonal nose' |
title_full_unstemmed |
Massive normalization of olfactory bulb output in mice with a 'monoclonal nose' |
title_sort |
massive normalization of olfactory bulb output in mice with a 'monoclonal nose' |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2016-05-01 |
description |
Perturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a “monoclonal nose”, glomerular input patterns in the olfactory bulb are massively perturbed and olfactory behaviors are altered. To gain insights into how olfactory circuits can process such degraded inputs we characterized odor-evoked responses of olfactory bulb mitral cells and interneurons. Surprisingly, calcium imaging experiments reveal that mitral cell responses in M71 transgenic mice are largely normal, highlighting a remarkable capacity of olfactory circuits to normalize sensory input. In vivo whole cell recordings suggest that feedforward inhibition from olfactory bulb periglomerular cells can mediate this signal normalization. Together, our results identify inhibitory circuits in the olfactory bulb as a mechanistic basis for many of the behavioral phenotypes of mice with a “monoclonal nose” and highlight how substantially degraded odor input can be transformed to yield meaningful olfactory bulb output. |
topic |
olfaction olfactory bulb signal normalization excitation/inhibition balance |
url |
https://elifesciences.org/articles/16335 |
work_keys_str_mv |
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