Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection

Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection

Green tea consumption reduces influenza incidence in human populations. However, where and how green tea exerts its anti-viral activities remain unclear. Here, we examined the adsorption of green tea catechins on the pharyngeal mucosa at 3–60 min after ingestion of green tea extract (GTE) and the ro...

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Main Authors: Shintaro Onishi, Takuya Mori, Hidetoshi Kanbara, Taichi Habe, Noriyasu Ota, Yuki Kurebayashi, Takashi Suzuki
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Journal of Functional Foods
Subjects:
Pharyngeal mucosa
Green tea catechins
Green tea extract
Epigallocatechin gallate
Influenza A virus
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620301183
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spelling doaj-17c0f99caf654873b07f6bc4730effa62021-04-30T07:18:38ZengElsevierJournal of Functional Foods1756-46462020-05-0168103894Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infectionShintaro Onishi0Takuya Mori1Hidetoshi Kanbara2Taichi Habe3Noriyasu Ota4Yuki Kurebayashi5Takashi Suzuki6Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanBiological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan; Corresponding author at: Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan.Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, JapanAnalytical Science Research, Kao Corporation, 1334 Minato, Wakayama-shi, Wakayama 640-8580 JapanBiological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanGreen tea consumption reduces influenza incidence in human populations. However, where and how green tea exerts its anti-viral activities remain unclear. Here, we examined the adsorption of green tea catechins on the pharyngeal mucosa at 3–60 min after ingestion of green tea extract (GTE) and the role this adsorption plays in preventing influenza A virus (IAV) infection in BALB/c mice. Green tea catechins were adsorbed on the pharyngeal mucosa for up to 60 min after GTE ingestion. The anti-IAV activity of GTE was dose dependent (p < 0.001). The anti-IAV activity of GTE peaked at 3 min after GTE ingestion and then gradually diminished; this was consistent with the amount of green tea catechins remaining on the pharyngeal mucosa. These results suggest that adsorption of green tea catechins on the pharyngeal mucosa is important for the anti-IAV activity of GTE.http://www.sciencedirect.com/science/article/pii/S1756464620301183Pharyngeal mucosaGreen tea catechinsGreen tea extractEpigallocatechin gallateInfluenza A virus
collection DOAJ
language English
format Article
sources DOAJ
author Shintaro Onishi
Takuya Mori
Hidetoshi Kanbara
Taichi Habe
Noriyasu Ota
Yuki Kurebayashi
Takashi Suzuki
spellingShingle Shintaro Onishi
Takuya Mori
Hidetoshi Kanbara
Taichi Habe
Noriyasu Ota
Yuki Kurebayashi
Takashi Suzuki
Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection
Journal of Functional Foods
Pharyngeal mucosa
Green tea catechins
Green tea extract
Epigallocatechin gallate
Influenza A virus
author_facet Shintaro Onishi
Takuya Mori
Hidetoshi Kanbara
Taichi Habe
Noriyasu Ota
Yuki Kurebayashi
Takashi Suzuki
author_sort Shintaro Onishi
title Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection
title_short Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection
title_full Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection
title_fullStr Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection
title_full_unstemmed Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection
title_sort green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza a virus infection
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2020-05-01
description Green tea consumption reduces influenza incidence in human populations. However, where and how green tea exerts its anti-viral activities remain unclear. Here, we examined the adsorption of green tea catechins on the pharyngeal mucosa at 3–60 min after ingestion of green tea extract (GTE) and the role this adsorption plays in preventing influenza A virus (IAV) infection in BALB/c mice. Green tea catechins were adsorbed on the pharyngeal mucosa for up to 60 min after GTE ingestion. The anti-IAV activity of GTE was dose dependent (p < 0.001). The anti-IAV activity of GTE peaked at 3 min after GTE ingestion and then gradually diminished; this was consistent with the amount of green tea catechins remaining on the pharyngeal mucosa. These results suggest that adsorption of green tea catechins on the pharyngeal mucosa is important for the anti-IAV activity of GTE.
topic Pharyngeal mucosa
Green tea catechins
Green tea extract
Epigallocatechin gallate
Influenza A virus
url http://www.sciencedirect.com/science/article/pii/S1756464620301183
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