Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology
Alpha-synuclein (α-syn) is a small protein that, in neurons, localizes predominantly to presynaptic terminals. Due to elevated conformational plasticity, which can be affected by environmental factors, in addition to undergoing disorder-to-order transition upon interaction with different i...
Main Authors: | Francesca Longhena, Gaia Faustini, Maria Grazia Spillantini, Arianna Bellucci |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-01-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/20/1/141 |
Similar Items
-
Pathological implications of the interaction between neurexins and alpha-synuclein in synucleinopathies
by: Fallon, Aurélie
Published: (2021) -
Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles
by: Luis D. Bernal-Conde, et al.
Published: (2020-01-01) -
Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits
by: Penelope J. Hallett, et al.
Published: (2012-08-01) -
Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
by: Allison J. Schaser, et al.
Published: (2020-08-01) -
Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts
by: Špela Korat, et al.
Published: (2021-08-01)