Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies
Polyneuropathy associated with IgM monoclonal gammopathy and anti-myelin associated glycoprotein (MAG) antibodies is an immune-mediated demyelinating neuropathy. The pathophysiology of this condition is likely to involve anti-MAG antibody deposition on myelin sheaths of the peripheral nerves and it...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2015/450391 |
id |
doaj-17cf4c479cf5478496f1612ee8e02d11 |
---|---|
record_format |
Article |
spelling |
doaj-17cf4c479cf5478496f1612ee8e02d112020-11-25T00:03:46ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/450391450391Heterogeneity of Polyneuropathy Associated with Anti-MAG AntibodiesLaurent Magy0Raphaël Kaboré1Stéphane Mathis2Prisca Lebeau3Karima Ghorab4Christiane Caudie5Jean-Michel Vallat6Department of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, FranceDepartment of Neurology, CHU Poitiers, University of Poitiers, 2 Rue de la Milétrie, 86021 Poitiers, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, FranceCentre de Biologie et de Pathologie Est, Hospices Civils de Lyon, 69000 Lyon, FranceDepartment of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 Avenue Martin Luther-King, 87042 Limoges, FrancePolyneuropathy associated with IgM monoclonal gammopathy and anti-myelin associated glycoprotein (MAG) antibodies is an immune-mediated demyelinating neuropathy. The pathophysiology of this condition is likely to involve anti-MAG antibody deposition on myelin sheaths of the peripheral nerves and it is supposed to be distinct from chronic inflammatory demyelinating neuropathy (CIDP), another immune-mediated demyelinating peripheral neuropathy. In this series, we have retrospectively reviewed clinical and laboratory findings from 60 patients with polyneuropathy, IgM gammopathy, and anti-MAG antibodies. We found that the clinical picture in these patients is highly variable suggesting a direct link between the monoclonal gammopathy and the neuropathy. Conversely, one-third of patients had a CIDP-like phenotype on electrodiagnostic testing and this was correlated with a low titer of anti-MAG antibodies and the absence of widening of myelin lamellae. Our data suggest that polyneuropathy associated with anti-MAG antibodies is less homogeneous than previously said and that the pathophysiology of the condition is likely to be heterogeneous as well with the self-antigen being MAG in most of the patients but possibly being another component of myelin in the others.http://dx.doi.org/10.1155/2015/450391 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laurent Magy Raphaël Kaboré Stéphane Mathis Prisca Lebeau Karima Ghorab Christiane Caudie Jean-Michel Vallat |
spellingShingle |
Laurent Magy Raphaël Kaboré Stéphane Mathis Prisca Lebeau Karima Ghorab Christiane Caudie Jean-Michel Vallat Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies Journal of Immunology Research |
author_facet |
Laurent Magy Raphaël Kaboré Stéphane Mathis Prisca Lebeau Karima Ghorab Christiane Caudie Jean-Michel Vallat |
author_sort |
Laurent Magy |
title |
Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies |
title_short |
Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies |
title_full |
Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies |
title_fullStr |
Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies |
title_full_unstemmed |
Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies |
title_sort |
heterogeneity of polyneuropathy associated with anti-mag antibodies |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2015-01-01 |
description |
Polyneuropathy associated with IgM monoclonal gammopathy and anti-myelin associated glycoprotein (MAG) antibodies is an immune-mediated demyelinating neuropathy. The pathophysiology of this condition is likely to involve anti-MAG antibody deposition on myelin sheaths of the peripheral nerves and it is supposed to be distinct from chronic inflammatory demyelinating neuropathy (CIDP), another immune-mediated demyelinating peripheral neuropathy. In this series, we have retrospectively reviewed clinical and laboratory findings from 60 patients with polyneuropathy, IgM gammopathy, and anti-MAG antibodies. We found that the clinical picture in these patients is highly variable suggesting a direct link between the monoclonal gammopathy and the neuropathy. Conversely, one-third of patients had a CIDP-like phenotype on electrodiagnostic testing and this was correlated with a low titer of anti-MAG antibodies and the absence of widening of myelin lamellae. Our data suggest that polyneuropathy associated with anti-MAG antibodies is less homogeneous than previously said and that the pathophysiology of the condition is likely to be heterogeneous as well with the self-antigen being MAG in most of the patients but possibly being another component of myelin in the others. |
url |
http://dx.doi.org/10.1155/2015/450391 |
work_keys_str_mv |
AT laurentmagy heterogeneityofpolyneuropathyassociatedwithantimagantibodies AT raphaelkabore heterogeneityofpolyneuropathyassociatedwithantimagantibodies AT stephanemathis heterogeneityofpolyneuropathyassociatedwithantimagantibodies AT priscalebeau heterogeneityofpolyneuropathyassociatedwithantimagantibodies AT karimaghorab heterogeneityofpolyneuropathyassociatedwithantimagantibodies AT christianecaudie heterogeneityofpolyneuropathyassociatedwithantimagantibodies AT jeanmichelvallat heterogeneityofpolyneuropathyassociatedwithantimagantibodies |
_version_ |
1725432208629432320 |