Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis

Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis

Liver fibrosis is an essential component of chronic liver disease (CLD) and hepatocarcinogenesis. The fibrotic stroma is a consequence of sustained liver damage combined with exacerbated extracellular matrix (ECM) accumulation. In this context, activation of hepatic stellate cells (HSCs) plays a key...

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Bibliographic Details
Main Authors: Marina Barcena-Varela, Leticia Colyn, Maite G. Fernandez-Barrena
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
Tumor microenvironment
fibrosis
hepatic stellate cells
epigenetic remodeling
Online Access:https://www.mdpi.com/1422-0067/20/10/2507

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