Downregulation of Autophagy-Related Proteins 1, 5, and 16 in Testicular Germ Cell Tumors Parallels Lowered LC3B and Elevated p62 Levels, Suggesting Reduced Basal Autophagy

Downregulation of Autophagy-Related Proteins 1, 5, and 16 in Testicular Germ Cell Tumors Parallels Lowered LC3B and Elevated p62 Levels, Suggesting Reduced Basal Autophagy

Autophagy is a cellular “self-digestion” process known to be essential for various physiological and pathological pathways, including cancer, where its role appears to be context-dependent. In this work, we aimed to investigate the level of autophagy by evaluating the expression of key autophagy-rel...

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Bibliographic Details
Main Authors: He Liu, Zhaoyue He, Peter Bode, Holger Moch, Hans-Uwe Simon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Oncology
Subjects:
testicular germ cell tumor (TGCT)
ATGs
LC3B
p62
autophagy
tumor suppression
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00366/full

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